Opioid peptides selective for mu- and delta-opiate receptors reduce calcium-dependent action potential duration by increasing potassium conductance |
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Authors: | M A Werz R L MacDonald |
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Institution: | Department of Neurology, University of Michigan, Ann Arbor, MI 48109 U.S.A. |
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Abstract: | We suggest that both mu- and delta-opiate receptors on dorsal root ganglion neuron somata are coupled to voltage- and/or calcium-dependent potassium channels since opioid peptide decreases of calcium-dependent action potential duration were: (1) not associated with a change of resting membrane potential or conductance; (2) accompanied by an increase in action potential after-hyperpolarization, and (3) blocked by intracellular injection of the potassium channel blocker cesium 18]. In contrast, norepinephrine 4] and cadmium 9], which have been reported to act on voltage-dependent calcium rather than potassium channels, shortened action potential duration and decreased after-hyperpolarization amplitude, an action not blocked by intracellular iontophoresis of cesium. |
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Keywords: | opiod peptide actions opioid receptors calcium action potential potassium conductance sensory ganglion neuron |
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