| 盐酸戊乙奎醚作为体外循环术前用药对认知功能障碍的影响 |
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| 引用本文： | 唐希,鲁开智. 盐酸戊乙奎醚作为体外循环术前用药对认知功能障碍的影响[J]. 重庆医学, 2010, 39(17). DOI: 10.3969/j.issn.1671-8348.2010.17.025 |
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| 作者姓名： | 唐希 鲁开智 |
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| 作者单位： | 第三军医大学西南医院麻醉科,重庆,400038;第三军医大学西南医院麻醉科,重庆,400038 |
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| 摘 要： | 目的观察盐酸戊乙奎醚用于体外循环心肺转流术(CPB),对心脏瓣膜置换患者术后认知功能障碍(POCD)的影响。方法根据简易精神状态(MMS)检测法评分对2009年1~9月40例心功能2~3级行心脏瓣膜置换的患者进行评价。随机分为盐酸戊乙奎醚组(P组)、空白组(C组),两组分别于麻醉诱导前30 min肌肉注射盐酸戊乙奎醚注射液0.015 mg/kg、生理盐水1mL。分别于气管插管后即刻(T1)、体外循环转机5 min后(T2)、体外循环低温恒温期(T3)、体外循环结束后5 min(T4)、手术结束后5 min(T5)、术后6 h(T6)、术后12 h(T7)、术后24 h(T8)、术后48 h(T9)共9个时间点进行动、静脉血气分析及血浆S100β蛋白浓度测定。结果 (1)两组患者的人口学特征、体检结果、基线情况(M0),以及CPB时间、主动脉阻断时间差异均无统计学意义(P>0.05)。(2)颈内静脉血氧饱和度(SjvO2)、脑氧代谢率(CERO2)比较:T2时各组SjvO2均下降,CERO2上升,T4时改变显著。各时间点P组SjvO2高于C组,CERO2低于C组,T8时已接近T1水平;C组T9时仍明显低于T1水...
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| 关 键 词： | 盐酸戊乙奎醚 术后认知功能障碍 S100β蛋白 体外循环心肺转流术 |
Effect of penehyelidine hydrochloride as preoperative medication in extra corporeal circulation on cognitive dysfunction |
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| TANG Xi,LU Kai-zhi. Effect of penehyelidine hydrochloride as preoperative medication in extra corporeal circulation on cognitive dysfunction[J]. Chongqing Medical Journal, 2010, 39(17). DOI: 10.3969/j.issn.1671-8348.2010.17.025 |
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| Authors: | TANG Xi LU Kai-zhi |
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| Affiliation: | TANG Xi,LU Kai-zhi(Departmant of Anesthesia,Southwest Hospital,Third Minlitary Medical University,Chongqing 400038,China) |
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| Abstract: | Objective To investigate the effects of pnehyclidine hydrochloride on cerebral ischemia-reperfusion injury and post operative cognitive dysfunction(POCD) in the patients undergoing valve replacement during cardiopulmonary bypass.Methods A total of 40 patients aged 15-55 years with cardiac function 2-3,received heart valve replacement form January 2009 to September 2009 were selected according to the mini-mental status(mini-mental state,MMS) detection.The patients were randomly divided into two groups(n= 20)... |
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