A comprehensive method for calculating total body irradiation |
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| Institution: | 1. Biophysics Department, Faculty of Science, Cairo University, Egypt;2. Radiation Oncology Department, Children''s Cancer Hospital, Egypt;3. Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt;4. Faculty of Commerce and Business Administration, Helwan University, Egypt;1. Health Sciences Research Centre, UCL University College, Campus Odense: UCL Erhvervsakademi og Professionshojskole, Campus Niels Bohrs Alle, Radiography, Odense, Denmark;2. Cardiology Research Department, Odense University Hospital, Svendborg, Denmark;3. Radiography and Diagnostic Imaging, School of Medicine, University College Dublin, Ireland;4. Department of Radiology and Nuclear Medicine, University Hospital of Southwest Jutland, Esbjerg, Denmark;5. Department of Regional Health Research, University of Southern Denmark, Denmark;6. Department of Radiology, Kolding, Lillebaelt Hospital, University Hospitals of Southern Denmark, Denmark;1. Trillium Health Partners, Credit Valley Hospital Site, 2200 Eglinton Ave W, Mississauga, ON L5M 2N1, Canada;2. Institute for Better Health, Trillium Health Partners, Canada;3. Institute for Health Policy, Management, & Evaluation, University of Toronto, Canada;4. Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milano, Italy;1. Department of Ultrasound, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China;2. Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China;1. The Christie NHS Foundation Trust, Department of Radiotherapy, Manchester, United Kingdom;2. Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom;3. Department of Clinical Oncology, The Christie NHS Foundation Trust, United Kingdom;4. Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, United Kingdom |
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| Abstract: | PurposeTo provide means for calculating the dose received by various tissues of the patient, calculate lung shield, and verify received dose using a phantom as a tool for quality assurance for a planned Total Body Irradiation (TBI) procedure in radiotherapy.MethodUsing Microsoft Visual Basic, MATLAB, and Python, a program for Total Body Irradiation Calculation in Radiotherapy (TBICR) is constructed. It uses patient translation and beam zone method for total body irradiation calculations to compute the proper dose received by the patient and determine the lung shield thickness. There are three main user-friendly interfaces in the application. The first one allows the user to upload the TBI topography and estimate the distances needed for TBI calculations. The second one enables the user to count the number of beam zones needed for each point and estimate the effective area (Aeff) for each level. The third interface estimates the velocity required to deliver the relative dose depending on patient separation, Monitor Units (MU), couch speed and travel distance. It allows the user to compute the required lung shield thickness, read any patient's CT DICOM file and acquire dose in any distinct location using machine learning model to predict the dose.ResultsThe TBICR software has been successfully validated by reproducing all of the manual calculations in an exact and timely manner. TBICR generated more accurate results and confirmed the absorbed dose to patient through measurements on Anderson phantom.ConclusionsA computer program for the calculation of total body irradiation (TBI) is described in full. The dose received at each point on the patient, the calculation of lung shield and the determination of the velocity and time required for the couch movement are all made possible using the software. The ease of use, precision, data storage and printing are some important features of the present software. |
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