白细胞介素5和支气管哮喘

支气管哮喘是由嗜酸性粒细胞、肥大细胞和T淋巴细胞等多种炎性细胞参与的气道慢性炎症。在这种非特异性炎症的发生发展中,嗜酸性粒细胞起关键性作用,白细胞介素5(IL-5)通过调节嗜酸性粒细胞的活化、聚集、脱颗粒等参与哮喘的发生和发展。随着分子生物学和分子遗传学的发展,有可能通过影响IL-5合成、分泌、抑制IL-5受体激活以及宿主IL-5受体信号转导等环节来治疗哮喘,这将会成为哮喘研究的一个新的方向。

Interleukin-5 and Bronchial Asthma

Bronchial asthma is chronic airway inflammation in w hich eosinophilic granulocyte,mast cell and T lymphocyte.During this nonspecific inflammation,e osinophilic granulocyte plays a critical role,and the interleukin-5(IL-5)pa rt icipate in the occurrence and development of asthma through regulation of activa tion,aggregation and doffing particles of eosinophilic granulocyte.With the de velopment of molecular biology and molecular genetics,the synthesis,secretion and inhibition of IL-5 activation and the sign...