子午流注择时针刺联合常规疗法治疗非痴呆型血管性认知障碍临床研究

目的：观察子午流注择时针刺联合常规疗法治疗非痴呆型血管性认知障碍（VCIND）的疗效。方法：选取110例VCIND患者，按随机数字表法分为对照组及观察组各55例。经脱落，最终对照组纳入52例，观察组53例。对照组给予常规西药治疗，观察组在对照组基础上联合子午流注择时针刺治疗。比较2组临床疗效及不良反应发生情况，比较2组治疗前后中医证候积分、脑血流动力学指标[血流速度（Vm）、舒张期最快血流速度（Vd）、收缩期最快血流速度（Vs）]、认知功能[蒙特利尔认知评估量表（MoCA)、简易精神状态检查量表（MMSE）]、血清相关因子水平[血清脑源性神经营养因子（BDNF）、同型半胱氨酸（Hcy）、胶质纤维酸性蛋白（GFAP）]的变化。结果：观察组临床疗效总有效率为92.45%，对照组为75.00%,2组比较，差异有统计学意义（P<0.05）。治疗后，2组中医证候积分均较治疗前下降（P<0.05），观察组中医证候积分低于对照组（P<0.05）。治疗后，2组Vs、Vd、Vm水平均较治疗前上升（P<0.05），观察组Vs、Vd、Vm水平均高于对照组（P<0.05）。治疗后...

Clinical Study on Midnight-Midday Ebb Flow Chrono-Acupuncture Combined withConventional Therapy for Vascular Cognitive Impairment of None Dementia

Abstract：Objective：To observe the curative effect of midnight-midday ebb flow chrono-acupuncturecombined with conventional therapy for vascular cognitive impairment of none dementia (VCIND). Methods：A total of 110 cases of VCIND patients were selected and divided into the control group and the observationgroup according to the random number table method，with 55 cases in each group. The control group wastreated with conventional western medicine treatment，and the observation group was additionally treatedwith midnight-midday ebb flow chrono-acupuncture based on the treatment of the control group. Clinicaleffects and the incidence of adverse reactions were compared between the two groups. The changes intraditional Chinese medicine syndrome (TCM) scores，cerebral hemodynamic indicators [blood flow velocity(Vm)， fastest diastolic blood flow velocity (Vd)， and fastest systolic blood flow velocity (Vs)]， cognitivefunction [Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE)]， levels ofserum-related factor [serum brain-derived neurotrophic factor (BDNF)， homocysteine (Hcy)， and glialfibrillary acidic protein (GFAP)] were compared between the two groups before and after treatment. Results：The total clinical effective rate was 92.45% in the observation group and 75.00% in the control group，thedifference being significant (P＜0.05). After treatment， TCM syndrome scores in the two groups weredecreased when compared with those before treatment (P＜0.05)， and the TCM syndrome scores in theobservation group were lower than those in the control group (P＜0.05). After treatment，the levels of Vs，Vd，and Vm in the two groups were increased when compared with those before treatment (P＜0.05)，andthe levels of Vs， Vd， and Vm in the observation group were higher than those in the control group (P＜0.05). After treatment，the scores of MoCA and MMSE in the two groups were increased when comparedwith those before treatment (P＜0.05)，and the scores of MoCA and MMSE in the observation group werehigher than those in the control group (P＜0.05). After treatment， the levels of BDNF in the two groupswere increased when compared with those before treatment， and the levels of Hcy and GFAP weredecreased when compared with those before treatment (P＜0.05)； the levels of Hcy and GFAP in theobservation group were lower than those in the control group (P＜0.05)， and the level of BDNF in theobservation group was higher than that in the control group (P＜0.05). The incidence of adverse reactionswas 5.66% in the observation group and 9.62% in the control group， there being no significance in thedifference (P＞0.05). Conclusion：Midnight-midday ebb flow chrono-acupuncture has significant effects inthe treatment of VCIND， which can reduce nerve cell damage， improve brain blood circulation， andenhance cognitive function，with high safety.