女性Ⅱ型糖尿病患者血清孕酮雌二醇与血清脂蛋白胆固醇水平的关系

报告了56例女性非胰岛素依赖性糖尿病患者(NIDDM)及31例正常对照者绝经后血浆雌二醇(E_2),孕酮(P)的水平,并测定了血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、HDL亚组分胆固醇(HDL_2-C和HDL_3-C)、低密度脂蛋白胆固醇(LDL-C VLDL-C)的水平。结果显示,NIDDM组血浆P,TC,LDL-C较对照组有显著意义的升高,而E_2/P,HDL_2-C,HDL_2-C/HDL_3-C,HDL_2-C/LDL-C VLDL-C较对照组降低,HDL_3-C及E_2两组间无显著性差异。NIDDM组血浆P与HDL_2-C/HDL_3-C和HDL_2-C/LDL-C呈负相关关系,这一结果提示NIDDM患者血浆脂蛋白胆固醇代谢紊乱,性激素水平的改变是女性NIDDM患者血清脂蛋白胆固醇代谢紊乱的影响因素之一。

THE RELATIONSHIPS BETWEEN PLASMA PROGESTERONE,ESTRADIOL AND SERUM CHOLESTEROL LEVELS OF DIFFERENT LIPOPROTEIN CLASSES IN POSTMENOPAUSAL NIDDM PATIENTS

56 postmenopausal NIDDM subjects and 31 normal postme- nopausal women were taken for this study.Plasma progesterone(P)and estradiol(E_2)were measured,and also total serum cholesterol(T-C),high density lipoprotein cholesterol(HDL-C)and its subfraction cholesterol (HDL_2-C,HDL_3-C),low density lipoprotein cholesterol(including very low density lipoprotein cholesterol)(LDL-C)were evaluated at the same time. P,T-C,LDL-C were significantly higher in NIDDM subjects than in con- trols.E_2/P,HDL-C,HDL_2-C,HDL_2-C/HDL_3-C,HDL_2-C/LDL-C were significantly lower in NIDDM subjects when compared with control group.HDL_3-C and E_2 were not significantly different between normal and NIDDM subjects.In NIDDM group,plasma progesterone level was negatively correlated to HDL_2-C/HDL_3-C and HDL_2-C/LDL-C(r=-0.3108 P<0.05,r=-0.3219 P<0.05).The results suggest that female meno- pausal NIDDM women have lipoprotein metabolic disorder,and the changed sex hormone levels may be one of these factors responsible for the lipoprotein cholesterol abnormality mentioned above.