骨代谢生化指标实验推荐方案

骨代谢生化指标包括钙磷代谢调节指标、骨形成标志物、骨吸收标志物、激素与细胞因子。其中骨形成标志物与骨吸收标志物合称为骨转换标志物。目前临床应用酶联免疫吸附测定、化学发光免疫测定、电化学发光免疫分析、放射免疫分析、免疫放射分析、高效液相色谱等方法检测血、尿中骨代谢生化指标水平,了解骨组织新陈代谢的情况,用于评价骨代谢状态、骨质疏松诊断分型、预测骨折风险、监测骨质疏松治疗疗效和代谢性骨病的鉴别诊断。本文复习了近年来中英文文献,总结了骨代谢生化指标的检测方法及原理,提出了骨代谢生化指标推荐方案。期待为骨代谢生化指标的推广和研究发挥积极作用。

Recommended protocol for bone metabolism biochemical index experiment

The biochemical indicators of bone metabolism include calcium and phosphorus metabolism regulation indicators, bone formation markers, bone resorption markers, hormones and cytokines. The bone formation markers and bone resorption markers are collectively called bone turnover markers. Enzyme-linked immunosorbent assay, chemiluminescence immunoassay, electrochemiluminescence immunoassay, radioimmunoassay, immunoradioassay, high performance liquid chromatography and other methods are currently used in clinical practice to detect the level of biochemical indicators of bone metabolism in blood and urine to understand the metabolism of bone tissue condition. Biochemical indicators of bone metabolism are used to evaluate the bone metabolism status, diagnostic classification of osteoporosis, predict fracture risk, evaluate the therapeutic effect of osteoporosis, and differential diagnosis of metabolic bone disease. This article reviewed the Chinese and English literature in recent years, summarized the detection methods and principles of bone metabolism biochemical indicators, and proposed a recommended plan for bone metabolism biochemical indicators. It is expected to play an active role in the promotion and research of biochemical indicators of bone metabolism.