Immunohistochemical localization of fibroblast growth factor-1 (FGF-l)and FGF-2 in cultured human ameloblastoma epithelial cells and ameloblastoma tissues |
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| Authors: | Y. Myoken Y. Myoken T. Okamoto J. D. Sato K. Takada |
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| Affiliation: | Department of Oral &Maxillofacial Surgery I, School of Dentistry, Hiroshima University, Japan;Department of Dentistry and Oral Surgery, Hiroshima Red Cross-Atomic Bomb Survivors Hospital, Japan;W. Alton Jones Cell Science Center, Lake Placid, New York, USA. |
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| Abstract: | ![]()
Fibroblast growth factor-1 (FGF-1) and FGF-2 are mitogenic polypeptides that may contribute to neoplastic cell proliferation. In the present study, we established a serum-free culture system for ameloblastoma cells and demonstrated that the addition of FGF-1 and FGF-2 enhanced cell growth in a dose-dependent manner. Immunoperoxidase staining of cultured cells demonstrated strong expression of FGF-1 and FGF-2. In tissue specimens, FGF-1 was localized in epithelial cell components of ameloblastomas, whereas FGF-2 was mainly found in the basement membranes with only moderate staining in epithelium. These data suggest that both FGF-1 and FGF-2 may contribute to the growth and development of ameloblastomas. |
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| Keywords: | ameloblastoma fibroblast growth factor-1 fibroblast growth factor-2 human |
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