青蒿及其提取物抗原虫作用的研究

青篙为传统的清热解毒中药,其提取物青篙素的抗疟作用已经证实。本文对青篙及其提取物抑制刚地弓形虫、杜氏利什曼原虫、冈比锥形虫、枯氏锥形虫、阴道毛滴虫、兰氏贾弟鞭毛虫和溶组织阿米巴的作用进行研究。发现对刚地弓形虫有明显的抗虫作用,对其他的原虫有部分抑制作用,并对其抗虫机制进行讨论。

In Vitro Antiparasitic Effects of Qinghao and its Extracts

Qinghao is a Chinese traditional herb.The effectiveness of its compound Qinghaosu against malaria is well estab- lished.Qinghao and its extracts were tested in vitro for antiparasitic activity against four aerobic parasites Toxo- plasma gondii,Leishmana donovani,Trypanosoma gambicnsia,and Trypanosoma cruzi,and three anerobic parasitcs Entamobca histolytica,Trichamonas vaginalis, and Giardia lamblia.This results show that Qinghao methanal extract and Qinghaosu completely eliminated T.gondii in fibroblasts,and prartly inhibited the growth of L.donovani and T.gambiensia.Qinghao water ex- tract and Qinghaosu also partly inhibited the growth of T.cruzi,of the 2 Qinghaosu derivatives tested, artemether was the move effective than that of Qinghao- su and dihydroqinghaosu.The datd suggests Qinghao and its extracts may be effective on against aerobic plas- modium.