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COVID-19-associated mucormycosis and treatments
Authors:Vetriselvan Subramaniyan  Shivkanya Fuloria  Hari Kumar Darnal  Dhanalekshmi Unnikrishnan Meenakshi  Mahendran Sekar  Rusli Bin Nordin  Srikumar Chakravarthi  Kathiresan V. Sathasivam  Shah Alam Khan  Yuan Seng Wu  Usha Kumari  Kalvatala Sudhakar  Rishabha Malviya  Vipin Kumar Sharma  Neeraj Kumar Fuloria
Abstract:In the current pandemic, COVID-19 patients with predisposing factors are at an increased risk of mucormycosis, an uncommon angioinvasive infection that is caused by fungi with Mucor genus which is mainly found in plants and soil. Mucormycosis development in COVID-19 patient is related to various factors, such as diabetes, immunocompromise and neutropenia. Excessive use of glucocorticoids for the treatment of critically ill COVID-19 patients also leads to opportunistic infections, such as pulmonary aspergillosis. COVID-19 patients with mucormycosis have a very high mortality rate. This review describes the pathogenesis and various treatment approaches for mucormycosis in COVID-19 patients, including medicinal plants, conventional therapies, adjunct and combination therapies.
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