大鼠坐骨神经固有频率测定

目的:确定实验大鼠坐骨神经的固有频率，观察不同状态下神经固有频率的变化，为神经再生修复研究中康复治疗仪器的频率选择提供参考。方法:将18只SD大鼠随机分为正常组、SNI 7 d组、SNI 28 d组，每组各6只，正常组不予干预，模型组行坐骨神经钳夹伤术。于造模后第7天通过振动平台对正常组、正常组的离体神经（即离体组）、SNI 7 d组，以及造模后第28天对SNI 28 d组大鼠施加振动频率源，在振动响应检测模块测得的数据基础上，根据频率特性曲线确定大鼠坐骨神经固有频率。结果:正常组、离体组、SNI 7 d组、SNI 28 d组大鼠坐骨神经频率特异性曲线均显示单一峰值；组间固有频率比较差异均无统计学意义（P=0.156）；组间两两比较显示，正常组与离体组、SNI 7 d组、SNI 28 d组比较，SNI 7 d组与SNI 28 d组比较，差异均无统计学意义（P>0.05）。固有频率检测值总体均数为9.635 Hz。结论:实验大鼠坐骨神经固有频率约为9.635 Hz，且固有频率是相对稳定的，不会因其所处状态不同而发生较大变化。

Determination of natural frequency of sciatic nerves in rats

Abstract: Objective To determine the natural frequency of sciatic nerves in experimental rats, and to observe the changes of natural frequency under different states, thereby providing a certain reference for the frequency selection of rehabilitation treatment instruments for the study on nerve regeneration and repair. Methods Eighteen SD rats were randomly divided into normal group, SNI 7 d group, and SNI 28 d group, with 6 rats in each group. The rats in normal group received no intervention, while those in model groups suffered from sciatic nerve clamp injuries. On the 7th day after modeling, the rats in normal group, isolated group (sciatic nerve isolation in normal group) and SNI 7 d group were subjected to a vibration frequency source on a vibration platform, and the same vibration frequency source was applied to SNI 28 d rats on the 28th day after modeling. Based on the data measured by the vibration response detection module, the natural frequency of sciatic nerves in rates was determined according to frequency characteristic curves. Results The frequency-specificity curves of sciatic nerves in normal group, isolated group, SNI 7 d group and SNI 28 d group all showed a single peak. No statistical significance was found in natural frequency among different groups (P=0.156). Pairwise comparison showed that there was no significant difference between normal group and isolated group, SNI 7 d group, SNI 28 d group, and that the difference between SNI 7 d group and SNI 28 d group was trivial (P>0.05). The overall mean natural frequency was 9.635 Hz. Conclusion The natural frequency of sciatic nerves in experimental rats is about 9.635 Hz, and the natural frequency is relatively stable and will not change greatly due to different states.