基于CT的影像组学特征同临床物理剂量特征预测肺癌放疗放射性肺炎研究

目的:探讨基于CT的影像组学特征同临床物理剂量特征预测肺癌放疗放射性肺炎研究。方法:回顾性收集2013年1月至2017年1月进行放射治疗的83例肺癌患者的临床物理剂量参数和CT影像以及随访数据。从病例的CT图像中提取107个影像组学特征，结合对应的45个临床物理剂量特征，每例病例共收集152个特征。基于22种特征提取算法和8种分类器构建的176个鉴别模型分析152个特征预测放射性肺炎的准确性以及筛选优势特征的能力。结果:临床物理剂量特征和影像组学特征预测放射性肺炎的鉴别模型中AUC值最高为0.90。前5位的优势特征是:shape_Maximum2DDiameterColumn、shape_Maximum3DDiameter、V20、glcm_Imc1、V45。结论:临床物理剂量特征和影像组学特征通过不同分类器和特征选择算法组合的鉴别模型，可以筛选出理想的鉴别模型以及优势预测特征。

Prediction of radiation pneumonia in lung cancer patients by CT-based radiomics signatures and clinical physical dosimetric features

Abstract: Objective To combine CT-based radiomics signatures with clinical physical dosimetric features for predicting radiation pneumonitis in lung cancer patients. Methods The clinical physical dosimetric features, CT images and follow-up data of 83 patients with lung cancer who underwent radiotherapy from January 2013 to January 2017 were retrospectively collected. A total of 152 features, including 107 radiomics signatures extracted from the CT images and 45 clinical physical dosimetric features, were collected for each case. Based on 22 feature extraction methods and 8 classifiers, 176 identification models were constructed to analyze the accuracy of 152 features in predicting radiation pneumonia and to evaluate the ability to screen dominant features. Results The highest AUC in the identification model for predicting radiation pneumonitis by clinical physical dosimetric parameter combined with radiomics signatures was 0.90. The top 5 dominant features included shape_Maximum2DDiameterColumn, shape_Maximum3DDiameter, V20, glcm_Imc1 and V45. Discussion The ideal identification model and superior prediction features can be screened from identification models constructed by the combination of different classifiers and feature selection algorithms based on clinical physical dosimetric features and radiomics signatures.