轮状病毒疫苗对深圳地区儿童腹泻临床特征的影响

目的探讨使用轮状病毒疫苗对儿童中轮状病毒肠炎临床特征的影响。方法收集2009～2010年因腹泻、急诊就诊的2月～3岁儿童,分为疫苗组和非疫苗组,比较其轮状病毒肠炎发病情况、平均住院天数及住院费用。结果所有急诊就诊的腹泻患儿中,疫苗组轮状病毒肠炎占11.8%,非疫苗组占39.4%,疫苗组并发症发生率为（10.2±2.1）%,平均住院天数（4.6±1.3）d,住院费用（1857.8±32.4）,三者均明显低于非疫苗组并发症发生率（31.7±8.2）%,平均住院天数（6.5±2.8）d,平均住院费用（2356.3±54.2）元,差异均有统计学意义。结论口服轮状病毒疫苗可以明显降低轮状病毒肠炎感染,缩短住院天数,降低住院成本。

Effect of rotavirus vaccine on acute gastroenteritis among children in Shenzhen city

Objectives To assess effect of rotavirus vaccine on acute rotavirus-associated gastroenteritis among Children in Shenzhen,by comparison of the rotavirus infection and the severity of rotavirus-associated diarrhea in vaccine age-eligible children（aged 2-36 months）with and without rotavirus vaccine implementation from 2009 to 2010.Methods All the children aged 2 months to 3 years visited doctors for diarrhea in our hospital from 2009 to 2010 were included,and divided into two groups,vaccine group and non-vaccine group.The incidence of rotavirus-associated gastroenteritis between the two groups was recorded.and the rate of complication,length of average hospital stay,and the sum of average hospitalization expenses were compared between the two groups.Results The incidence rate of rotavirus gastroenteritis was 11.8% in vaccine group and 39.4% in non-vaccine group.The incidence of complication,duration of average hospital stay,and sum of average hospitalization expenses were 10.2±2.1%,4.6±1.3 days,1857.8±32.4 Yuan in vaccine group,and 31.7±8.2%,6.5±2.8 days,2356.3±54.2 Yuan in non-vaccine group,respectively.Conclusions The immunization with rotavirus vaccine can apparently reduce incidence of gastroenteritis due to rotovirous infection among children,,shorten duration of hospital stay,reduce expense.