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| 细胞膜色谱技术及其在中药活性成分筛选和安全性评价中的应用 | |
| 引用本文： | 陈颖,柏自松,朱彦,张鹏. 细胞膜色谱技术及其在中药活性成分筛选和安全性评价中的应用[J]. 天津中医药大学学报, 2015, 34(6): 373-378 |
| 作者姓名： | 陈颖 柏自松 朱彦 张鹏 |
| 作者单位： | 天津中医药大学, 天津市现代中药重点实验室, 天津 300193,天津中医药大学, 天津市现代中药重点实验室, 天津 300193;天津国际生物医药联合研究院, 天津 300457,天津中医药大学, 天津市现代中药重点实验室, 天津 300193,天津中医药大学, 天津市现代中药重点实验室, 天津 300193 |
| 基金项目： | 国家自然科学基金青年项目(81303183,81274128). |
| 摘 要： | 细胞膜色谱法是一种可在体外模仿药物与靶点相互作用的生物色谱方法,目前已经广泛应用于活性成分的筛选中。通过概述细胞膜色谱技术的发展过程,详细总结了细胞膜色谱法用于中药活性成分筛选及安全性评价过程中所针对的疾病、靶点及涉及的细胞类型、中药和化学成分类型,并探讨其在应用过程中的局限性。 |
| 关 键 词： | 细胞膜色谱 中药 活性筛选 安全性评价 |
| 收稿时间： | 2015-07-15 |
Cell membrane chromatography and application of it in screening active components and security evaluation of traditional Chinese medicine |
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| CHEN Ying,BAI Zi-song,ZHU Yan and ZHANG Peng. Cell membrane chromatography and application of it in screening active components and security evaluation of traditional Chinese medicine[J]. Journal of Tianjin University of Traditonal Chinese Medicine, 2015, 34(6): 373-378 | |
| Authors: | CHEN Ying BAI Zi-song ZHU Yan ZHANG Peng |
| Affiliation: | Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China;Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China,Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China and Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China |
| Abstract: | Cell membrane chromatography(CMC), which imitates interaction of drug and target in vitro, has been widely used for screening active components. This paper reviewed the development process of CMC technology, as well as summarized the diseases, targets, cell types, tradional Chinese medicine types and chemical composition types involved in the past screening research. Also we discussed the limitation of CMC in the application field. |
| Keywords: | cell membrane chromatography traditional Chinese medicine activity screening security evaluation |
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