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| PI3K／AKT信号通路在子宫内膜癌中的研究进展 | |
| 引用本文： | 李霞[综述] 潘晓琳 李锋[审校]. PI3K／AKT信号通路在子宫内膜癌中的研究进展[J]. 世界肿瘤杂志, 2010, 0(3): 141-144 |
| 作者姓名： | 李霞[综述] 潘晓琳 李锋[审校] |
| 作者单位： | 石河子大学医学院新疆地方与民族高发病实验室,病理学教研室,新疆石河子832002 |
| 摘 要： | PI3K／Akt信号通路是许多细胞外因子的下游信号传导通路，在细胞生长、增殖、分化和凋亡中起到重要作用，该通路异常广泛存在于许多恶性肿瘤中，与肿瘤发生、发展密切相关。在子宫内膜癌发生发展中，PI3K／Akt信号传导通路异常起到重要的作用，通过对该通路的进一步研究，可能为子宫内膜癌的发生机制、诊断以及为临床靶向治疗提供新的思路。 |
| 关 键 词： | PI3K／Akt信号通路 PIK3CA Akt PTEN 子宫内膜癌 |
The Research of PI3K/Akt signaling pathway in endometrial carcinoma |
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| Affiliation: | LI Xia, PAN Xiao-lin, LI Feng (Laboratory of Xinjiang Endemic and Ethnic Disease, Department of Pathology, College of Medicine, Shihezi University, Shihezi, Xinjiang, 832002, China) |
| Abstract: | PI3K/Akt signaling pathway is the downstream signal transduction pathway of many extracellular factors, play an important role in cell growth, proliferation, differentiation and apoptosis, the abnormal pathway exists widely in many malignant tumors, and is closely related to cancer development. In the development of endometrial carcinomas, PI3K/Akt signaling pathway plays an important role in endometrial carcinomas. Further study of the pathway may provide new ideas for the mechanism research, the clinical diagnosis and targeted therapy of endometrial carcinomas. |
| Keywords: | PI3K-Akt signaling pathway PIK3CA Akt PTEN endometrial carcinoma |
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