| 氯化锂可恢复脆性X综合征小鼠记忆行为和糖原合成酶激酶3β的活性 |
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| 作者姓名： | 陈盛强 Kaiyi Cao Lijun Dai Weiwen Sun Xi Chen Yueling Huang Chen xi 易咏红 Xuegang Luo Quan Yang |
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| 作者单位： | 广州医学院第二附属医院神经研究所,Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province, the Ministry of Education, Institute of Neuroscience, Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, Guangdong Province, China,Laboratory Animal Research Center of Guangzhou Medical College, Guangzhou 510182, Guangdong Province, China,Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province, the Ministry of Education, Institute of Neuroscience, Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, Guangdong Province, China,Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province, the Ministry of Education, Institute of Neuroscience, Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, Guangdong Province, China,Laboratory Animal Research Center of Guangzhou Medical College, Guangzhou 510182, Guangdong Province, China,Guangzhou Medical College,广州医学院第二附属医院神经研究所,Department of Human Anatomy and Neurobiology, College of Basic Medicine, Central South University, Changsha 410013, Hunan Province, China,Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province, the Ministry of Education, Institute of Neuroscience, Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, Guangdong Province, China |
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| 基金项目： | the National Natural Science Foundation of China,No.30870876;the Natural Science Foundation of Guangdong Province,No.815101700100005;the Science and Technology Program of Guangdong Province,No.2005B60302004,2008B030301371,2009B030801368;the Traditional Chinese Medicineand Combination of Traditional Chinese and Western Medicine Program of Guangzhou,No.2008A52;the Medical and Health Scientific Research Program of Guangzhou,No.2009-YB-167 |
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| 摘 要： | In the present study,Fmr1 knockout mice (KO mice) were used as the model for fragile X syndrome.The results of step-through and step-down tests demonstrated that Fmr1 KO mice had shorter latencies and more error counts,indicating a learning and memory disorder.After treatment with 30,60,90,120,or 200 mg/kg lithium chloride,the learning and memory abilities of the Fmr1 KO mice were significantly ameliorated,in particular,the 200 mg/kg lithium chloride treatment had the most significant effect.Western blot analysis showed that lithium chloride significantly enhanced the expression of phosphorylated glycogen synthase kinase 3 beta,an inactive form of glycogen synthase kinase 3 beta,in the cerebral cortex and hippocampus of the Fmr1 KO mice.These results indicated that lithium chloride improved learning and memory in the Fmr1 KO mice,possibly by inhibiting glycogen synthase kinase 3 beta activity.
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| 关 键 词： | fragile X syndrome Fmr1 knockout mice step-down test step-through test learning and memory glycogen synthase kinase 3 beta lithium chloride |
| 收稿时间： | 2011-06-08 |
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