Individual and combined relationship of serum uric acid and alanine aminotransferase on metabolic syndrome in adults in Qingdao,China |
| |
| Institution: | 1. Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong 266071, China;2. Qingdao Cancer Institute, Qingdao, Shandong 266071, China;3. Qingdao Municipal Center for Disease Control and Prevention, Qingdao, Shandong 266033, China;4. Qingdao Institute of Preventive Medicine, Qingdao, Shandong, 266033, China;5. School of Life Sciences, Tsinghua University, Beijing, 100084, China;1. Department of Cardiac Function, The People''s Hospital of China Medical University and the People''s Hospital of Liaoning Province, Shenyang 110016, China;2. Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;3. Department of Ultrasonography, The People''s Hospital of Zhengzhou University, Zhengzhou 450003, China;4. Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;1. Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore;2. Université de Paris, CRESS, Inserm, INRAE, F-75004 Paris, France;3. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore;4. Department of Maternal Fetal Medicine, KK Women''s and Children''s Hospital, Singapore;5. Department of Paediatric Endocrinology, KK Women''s and Children''s Hospital, Singapore;6. Duke-NUS Medical School, Singapore;7. Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore;8. Liggins Institute, University of Auckland, New Zealand;9. MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, UK;10. Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore;11. Department of Reproductive Medicine, KK Women''s and Children''s Hospital, Singapore;12. Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore;1. Department of Medical Biochemistry, University of Belgrade – Faculty of Pharmacy, Belgrade, Serbia;2. Department of Laboratory Diagnostics, University Medical Center “Be?anijska kosa”, Belgrade, Serbia;3. Department of Cardiology, University Medical Center “Be?anijska kosa” and University of Belgrade-Faculty of Medicine, Belgrade, Serbia;4. Department of Pulmonology, University Medical Center “Be?anijska kosa”, Belgrade, Serbia;1. Department of Geriatric Medicine, Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, 410008, China;2. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China;3. Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China;4. Department of Cardiovascular Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China;1. General Medicine C, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy;2. Liver Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy;3. UCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London, UK;4. Unit of Internal Medicine and Metabolic Disease, Ca’ Granda IRCCS Foundation, Policlinico Hospital, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy |
| |
| Abstract: | Background and aimsAssociations of alanine aminotransferase (ALT) and serum uric acid (SUA) with metabolic syndrome (MetS) remain controversial. We aimed to explore individual and combined effects of ALT and SUA on MetS in community residents.Methods and resultsA population-based cross-sectional survey involving randomly selected Chinese adults aged 35–74 years was conducted in 2009 in Qingdao, China, and 4642 participants were included in the current study. Based on a combination of SUA and ALT levels in the tertile, subjects were grouped into Group 1-9. The individual and combined relations of SUA and ALT to MetS were analyzed by logistic regression models. The prevalence of MetS was 28.50% in males and 22.30% in females. ALT and SUA were independently associated with MetS and ORs (95% CIs) were 1.55 (1.42–1.70) and 1.92 (1.72–2.14), respectively, after adjusting for potential confounders. With the elevation of ALT and SUA levels, the risk of developing MetS increased. Compared to Group 1, ORs (95% CIs) of combined ALT and SUA for MetS were 2.21 (1.70–2.88), 4.02 (3.10–5.21), 2.19 (1.62–2.97), 2.53 (1.91–3.34), 4.69 (3.60–6.12), 1.76 (1.17–2.64), 3.65 (2.63–5.06) and 7.15 (5.41–9.46) in Group 2–9, respectively.ConclusionsALT and SUA were both related to MetS independently. Combined elevation of ALT and SUA levels could increase the risk of MetS and its components than an elevation in SUA and ALT alone. Therefore, measures should be taken to lower SUA and ALT levels to reduce the risk of having MetS. |
| |
| Keywords: | Alanine aminotransferase Serum uric acid Metabolic syndrome |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
