2002年-2011年广西肿瘤医院6173例肝恶性肿瘤分析

目的：分析近十年来广西肿瘤医院肝恶性肿瘤患者的年龄、性别、民族及地区分布,病理类型情况和转归,以了解本地区肝恶性肿瘤发病趋势,为临床防治工作提供依据.方法：按照国际疾病分类（ICD-10）肿瘤形态学及肝恶性肿瘤病理分类原则进行检索,收集我院2002年-2011年肝恶性肿瘤首次入院病例进行统计分析.结果：2011年首次入院人数比2002年增加78.6％.男女比7.14∶1,发病高峰年龄30-60岁,30岁以后发病率为94.5％.就诊患者多来自广西中南部地区,其中汉族和壮族就诊人数占98％以上.原发性肝癌占肝恶性肿瘤的97.7％,其它肝恶性肿瘤（如神经内分泌瘤、纤维肉瘤、血管肉瘤等）占2.3％.甲胎蛋白（AFP）阳性者为71.8％,HBsAg阳性率为80.4％,两者皆为阳性者62.8％,两者皆为阴性者10.6％.234例发生转移的恶性肿瘤中,肝内转移占35.0％、肺转移34.6％、骨转移9.4％、脑转移3.0％、周围淋巴结15.4％、其它2.6％.结论：近年来本地区肝恶性肿瘤患病人数快速增加,且男性远多于女性,各个年龄段均可发病,30岁以后为高发人群.本病好发于广西中南部地区,民族之间无差异.病理学分型主要以原发性肝细胞癌为主,混合性肝癌较少见.HBsAg和AFP与肝癌关系密切,且HBsAg和AFP可能存在一定的相关性.十年来我院采用手术和联合治疗的方法,使肝恶性肿瘤的治愈率不断上升,死亡率逐年下降.

The analysis of 6173 cases of hepatic malignant tumor from 2002 to 2011 in Guangxi Tumor Hospital

Objective：To analyze features of age,gender,ethnicity and geographical distribution,pathological type and outcome of hepatic malignancy in Guangxi Tumor Hospital in recent ten years.Methods：Collected the data of first admission cases of liver malignancies from 2002 to 2011 in our hospital.Results：The admissions for the first time in 2011 than in 2002 increased by 78.6％,male and female ratio was 7.14∶ 1.The peak incidence of age was between 30-60 years old,after the age of 30 the incidence rate was 94.5 ％ ;most patients came from the areas of central and southern Guangxi,in which ethnic groups Han and Zhuang accounted for more than 98％.Primary liver cancer accounts for 97.7％ of the malignant tumors of the liver,other malignant liver tumors（such as neuroendocrine tumor angiosarcoma,fibrosarcoma） accounted for 2.3％.AFP positive in 71.8％ and HBsAg positive in 80.4％,both were positive in 62.8％,both were negative in 10.6％.Intrahepatic metastasis in 234 cases of metastasis of malignant tumors accounted for 35.0％,34.6％ lung metastases,bone metastases 9.4％,3.0％ brain metastases,the lymph nodes around 15.4％,other 2.6％.Conclusion：In recent years,the region of malignant liver tumors rapidly increased and the incidence of men was far more than women.The disease occurs in the central and southern areas in Guangxi and there is no difference between ethnic groups.The main histological type was primary hepatocellular carcinoma,the mixed liver cancer is less common.HBsAg and AFP was closely related to liver cancer.