Umbilical artery velocity waveforms and intrauterine growth retardation |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Bronx Municipal Hospital Center, Albert Einstein College of Medicine of Yeshiva University, Mineola, New York USA;2. State University of New York at Stony Brook, Mineola, New York USA;3. Department of Obstetrics and Gynecology, Nassau Hospital, Mineola, New York USA;1. Zekai Tahir Burak Women Health Care Education and Research Hospital, Ankara, Turkey;2. Bozok University, Yozgat, Turkey;1. Duke University Medical Center, 27710, Durham, NC, USA;2. University of California San Francisco, Fresno, CA, USA;3. University of Kansas Medical Center, Kansas City, KS, USA;4. Cytokinetics, Inc., San Francisco, CA, USA;1. Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA;2. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA;1. Altınbaş University Faculty of Medicine, Department of Obstetrics and Gynecology, and Gynecologist in Hera Women''s Health Center, Istanbul, Turkey;2. Hera Women''s Health Center, Istanbul, Turkey;3. Altınbaş University Faculty of Medicine, Department of Obstetrics and Gynecology, Istanbul, Turkey;4. Medipol University Faculty of Medicine, Department of Obstetrics and Gynecology, Istanbul, Turkey;1. Department of Otolaryngology – Head & Neck Surgery, University of North Carolina, School of Medicine, CB #7070, Chapel Hill, NC 27599-7070, USA;2. Edward P. Fitts Department of Industrial and Systems Engineering, North Carolina State University, 414-D Daniels Hall, CB#7906, Raleigh, NC 27695-7906, USA |
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| Abstract: | ![]()
A continuous-wave Doppler unit was used to obtain umbilical artery velocity waveforms and to calculate the peak-systolic/diastolic ratio, a reflection of vascular resistance distal to the point of measurement. A total of 587 examinations were performed on 189 women between 18 to 42 weeks' gestation. The neoriates were divided in four groups based on their centile birth weight: <25%, 25% to 50%, 51% to 75%, and >75% for that gestational age. In all four groups the placental vascular resistance as reflected by the systolic/diastolic ratio fell progressively from the 24 weeks onward. In the lower weight group, placental vascular resistance between 31 to 39 weeks' gestation was higher than in the other three groups (p < 0.05). For measurements taken between 31 and 39 weeks' gestation we calculated the predictive value of this test in identifying the small-for-gestational age fetus. A ratio of ≥3 was defined as abnormal. For the entire population tested, sensitivity was 78% and the specificity was 83%. The predictive value of a positive test was 49%, but when hypertension was present, it was 66%. These findings may prove useful in identifying and managing pregnancies at risk for intrauterine growth retardation. |
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