首页 | 本学科首页   官方微博 | 高级检索  
     

胆管结扎肝硬化犬血浆TXA_2/PGI_2变化及其与门脉血液动力学的关系
引用本文:黄自平,梁扩寰. 胆管结扎肝硬化犬血浆TXA_2/PGI_2变化及其与门脉血液动力学的关系[J]. 中国病理生理杂志, 1993, 0(3)
作者姓名:黄自平  梁扩寰
作者单位:宜昌医专内科教研室,同济医科大学同济医院肝病研究所 武汉 430030
摘    要:为阐明肝硬化时TXA_2/PGI_2的代谢状况及其与门脉高压的关系,我们研究了慢性胆管结扎犬肝硬化时血浆TXB_2/6-keto-PGF_(1α)变化及其与门脉血液动力学的关系。结果表明,肝硬化犬下腔静脉TXB_2水平与正常犬相近(P>0.05),肝静脉显著高于正常犬(P
关 键 词:肝硬变  血液动力学  门脉高压  前列素X类  血栓素A_2

Relationship between splanchnic plasma thromboxane A_2/prostacyclin levels and portal hemodynamics in cirrhotic dogs
Huang Zi-Ping,Liang Kuo-Huan Institute of Hepatology,Tongji Hospital,Tongji Medical University,Wuhan. Relationship between splanchnic plasma thromboxane A_2/prostacyclin levels and portal hemodynamics in cirrhotic dogs[J]. Chinese Journal of Pathophysiology, 1993, 0(3)
Authors:Huang Zi-Ping  Liang Kuo-Huan Institute of Hepatology  Tongji Hospital  Tongji Medical University  Wuhan
Abstract:To explore the metabolic state of A_2/PGI_2 and their relations to portalhypertension in cirrhosis, splanchnic plasma levels of TXA_2 and PGI_2 were measured byRIA in chronic bile-duct-ligation-induced cirrhotic dogs. The results showed that, in thecirrhotics, TXA_2 content of inferior vana cava was not elevated, but that of hepatic veinwas significantly increased, and that of portal vein was notably decreased as compared withthe controls. Prostacyclin concentrations of inferior vana cava, hepatic and portal veins inthe cirrhotic dogs were much higher than that of the control dogs, but the ratio of TXA_2to PGI_2 was notably reduced compare with the normal. There was no relation found betweenTXA_2 or PGI_2 and portal hemodynamics in the control. However, a negative correla-tion between PGI_2 and total hepatic blood flow and a positive correlation between TXA_2or TXA_2/PGI_2 ratio and hepatic arterial blood flow were found in the cirrhotics. Theseresults suggested that the cirrhotic dogs have an abnormal TXA_2/PGI_2 metabolite andTXA_2 may play a beneficial role in the maintenance of efficient hepatic perfusion in cir-rhosis.
Keywords:Liver cirrhosis  Hemodynamica  Hypertension portal  Prostaglandlins X  Thromboxane A_2  
本文献已被 CNKI 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号