Antinociceptive and anti-inflammatory effects of isolated fractions from Apium graveolens seeds in mice |
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| Authors: | Mina Ramezani Sima Nasri Narguess Yassa |
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| Affiliation: | 1. Department of Biology, Islamic Azad University, Ashtian Branch, Ashtian, Iranmina.ramezani@gmail.com;3. Department of Biology, Payame Noor University, Center of Tehran, Tehran, Iran;4. Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences and Medicinal Plant Research Center, Tehran, Iran |
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| Abstract: | ![]()
The antinociceptive and anti-inflammatory effects of the aqueous and hexane extracts obtained from Apium graveolens L. (Apiaceae) seeds were evaluated. Formalin and xylene-induced ear edema tests were used in mice. The fractions were administered intraperitoneally at doses of 100-500?mg/kg body weight (BW). Both extracts with the xylene-induced ear edema test showed significant anti-inflammatory activity at all doses as compared with control. Only the hexane fraction reduced the nociception produced by formalin solution in the first phase (0-5?min) at 300, 400, and 500?mg/kg BW, and in the second phase (20-30?min) at 500?mg/kg BW. It is concluded that the hexane fraction has major contribution to the overall antinociceptive activity. Both fractions showed remarkable anti-inflammatory effect which supported the traditional use of Apium graveolens in diseases associated with inflammation. |
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| Keywords: | Anti-inflammatory activity antinociceptive activity Apiaceae Apium graveolens |
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