Prognostic impact of hs-CRP and IL-6 in patients undergoing radiofrequency catheter ablation for atrial fibrillation |
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Authors: | Vassiliki Pitiriga John Lekakis Vasilios Kotsis Athanasios Protogerou Ignatios Ikonomidis Vassilike Gennimata |
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Affiliation: | 1. Department of Microbiology, “Alexandra” Hospital, Lourou &2. Vas. Sofias 80, 11528, Athens, GreeceSpytiriga@yahoo.com;4. Department of Clinical Therapeutics, Medical School of Athens, “Alexandra” Hospital, Lourou &5. Vas. Sofias 80, 11528, Athens, Greece |
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Abstract: | Background. We investigated the possible association between antichlamydial antibodies and pulse wave analysis (PWA) parameters in a cohort of patients with coronary artery disease (CAD). Methods. The augmentation index (AI), the reflection time index (RTI) and the time to the beginning of the reflected wave (CT-1) were estimated (Sphygmocor ATCOR Medical). IgA titers?≥?40 and IgG ≥80 were considered as positive (microimmunofluorescence test). Patients also underwent coronary angiography, ultrasound carotid measurements and 24 h ambulatory blood pressure (BP) measurements. Results. No differences existed in the traditional risk factors for CAD between the seronegative and seropositive IgA/ IgG groups. IgA seropositive subjects had higher values of AI (p?0.01) comparing to seronegatives whilst the levels of CT-1 and RTI were lower (p?0.011 and p?0.02 respectively). No differences in AI, CT-1 and RTI values were found between IgG seropositive/ seronegatives patients. Conclusions. An association was indicated between IgA antichlamydial titers and PWA parameters in patients with CAD, supporting that the connecting link between arterial stiffness and CAD might include this microorganism. |
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Keywords: | Arterial stiffness coronary artery disease C. pneumoniae infection |
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