| HPLC法测定莱阳梨止咳糖浆中盐酸麻黄碱含量 |
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| 引用本文： | 王洪明,耿海霞. HPLC法测定莱阳梨止咳糖浆中盐酸麻黄碱含量[J]. 解放军药学学报, 2013, 0(3): 252-253 |
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| 作者姓名： | 王洪明 耿海霞 |
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| 作者单位： | [1]滨州市药品检验所,山东滨州256618 [2]滨州市食品药品监督管理局滨城区分局,山东滨州256600 |
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| 摘 要： | 目的建立以HPLC法测定莱阳梨止咳糖浆中盐酸麻黄碱含量的方法。方法 Agilent Extend C18色谱柱（250mm×4.6 mm,5μm）,以乙腈-0.1%磷酸溶液（含0.1%三乙胺）（10∶90）为流动相,检测波长为207 nm。结果盐酸麻黄碱进样量在0.0700～1.400μg的范围内线性关系良好（r=1.0000）,平均回收率为99.7%。结论本实验方法简单,结果准确,重复性好,可用于对莱阳梨止咳糖浆中盐酸麻黄碱含量进行控制。
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| 关 键 词： | HPLC 莱阳梨止咳糖浆 盐酸麻黄碱 含量测定 |
Determination of Ephedrine Hydrochloride in Laiyangli Cough Syrup by HPLC |
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| WANG Hong-ming,GENG Hai-xia. Determination of Ephedrine Hydrochloride in Laiyangli Cough Syrup by HPLC[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2013, 0(3): 252-253 |
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| Authors: | WANG Hong-ming GENG Hai-xia |
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| Affiliation: | Binzhou Institute for Drug Control,Binzhou 256618,China; Bincheng Food and Drug Administration, Binzhou 256600, China |
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| Abstract: | Objective To establish an RP-HPLC method for the determination of Ephedrine Hydrochloride in Laiyangli cough syrup. Methods Agilent Extend C18 column was used. The mobile phase consisted of acetonitrile- 0.1% phosphoric acid （0.3% triethyamine） （ 10： 90）. The detection wavelength was set at 207 nm. Results A good linearity was obtained in the range of 0.0700 μg to 1. 400 μg（ r = 1. 0000）. The average recovery was 99.7%. Con- clusion This method is simple ,accurate,reproducible and can be used for laiyangli cough syrup quality control. |
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| Keywords: | HPLC laiyangli cough syrup ephedrine hydrochloride determination |
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