转移抑制候选基因 MIM

转移抑制基因是一类只抑制癌细胞的转移但不影响肿瘤发生和生长的基因.MIM是一种新近发现的肿瘤转移抑制候选基因,所编码的蛋白在转移性膀胱癌和前列腺癌等肿瘤中比其在正常组织中低表达.MIM基因定位于染色体8q24.1上,通过一段富含脯氨酸的序列和具有的WH2结构域结合肌动蛋白,具有调控细胞骨架的作用,其多结构域的特点使其还具备支架作用.MIM可能的同系物MIM-B同样被认为编码一种假定的转移抑制蛋白.

Tumor metastasis suppressor gene MIM

Tumor metastasis suppressor genes is a kind of genes that only suppresses tumor metastasis without affecting tumorigenesis and tumor growth. MIM ( missing in metastasis ) is a putative tumor metastasis suppressor gene discovered recently, which is thought to be down-regulated generally in some metastatic bladder cancer and prostate cancer cells in comparison with normal bladder and prostate tissue. MIM, localized in chro-mosome 8q24.1, suggests a connection with regulation of cytoskeleton with a proline-rich region and a homology 2 (WH2) domain binding the actin. MIM also has support roles for its multiple-domain. Its potential homo-logue MIM-B is also thought to code a putative tumor metastasis suppressor protein.