| 生长激素在肝纤维化患者中的应用 |
| |
| 引用本文： | 李瑞麟,杨芳.生长激素在肝纤维化患者中的应用[J].安徽医药,2012,16(5):689-692. |
| |
| 作者姓名： | 李瑞麟 杨芳 |
| |
| 作者单位： | 安徽医科大学附属第三医院药学部,安徽,合肥,230061;安徽医科大学第二附属医院妇产科,安徽,合肥,230601 |
| |
| 摘 要： | 生长激素不但能在生长过程中起重要作用,而且在碳水化合物,脂类代谢过程中起重要作用。慢性肝病的一个重要特征是生长激素抵抗现象,其表现为血清中生长激素的浓度较高而胰岛素样生长因子-1的水平降低。使用生长激素治疗慢性肝病,可提高患者血清中胰岛素样生长因子-1和胰岛素样生长因子结合蛋白-3升高,改善患者的生长激素抵抗现象,改善肝功能,纠正低蛋白血症。该文就使用生长激素治疗慢性肝病和肝纤维化的研究现状做一简要综述。
|
| 关 键 词： | 生长激素 胰岛素样生长因子 肝纤维化 |
Application of growth hormone therapy in patients with liver cirrhosis |
| |
| LI Rui-lin
,
YANG Fang.Application of growth hormone therapy in patients with liver cirrhosis[J].Anhui Medical and Pharmaceutical Journal,2012,16(5):689-692. |
| |
| Authors: | LI Rui-lin YANG Fang |
| |
| Institution: | 1.Department of Pharmacy,The Third Hospital Affiliated to Anhui Medical University,Hefei,Anhui 230061,China; 2.Depatement of Obstetrics,The Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230601,China) |
| |
| Abstract: | Growth hormone is important not only in growth action,but also in very wide fields,such as carbohydrate and lipid metabolism.Chronic liver cirrhosis is characterized as one of the growth hormone resistant states,whereby GH serum levels are high in the presence of low insulin-like growth factor-1 serum levels.Insulin-like growth factor-I and insulin-like growth factor binding protein-3 concentrations is increased in human growth hormone treated patients.Growth hormone can improve liver function effectively,prevent growth hormone resistant states,increase serum albumin concentration in patients with chronic liver disease and cirrhosis.The present situation concerning the therapeutic effect of growth hormone therapy in patients with chronic liver disease and cirrhosis is reviewed. |
| |
| Keywords: | growth hormone insulin-like growth factor liver cirrhosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
