血府逐瘀胶囊治疗糖尿病肾病的临床观察

观察血府逐瘀胶囊对早中期糖尿病肾病(DN)血瘀证的疗效,采用随机方法将60例早中期DN患者,分为血府逐瘀胶囊治疗组和科素亚对照组各30例,疗程为8周,观察治疗前后两组临床症状积分、24小时尿蛋白定量、肾功能、血脂、血纤维蛋白原(FIB)、D-二聚体(DD)、血液流变学等变化。结果治疗组总有效率为76.6%,明显优于对照组的56.7%(P<0.05);血瘀症状改善率治疗组为84.6%,对照组为58.1%(P<0.05,P<0.01);两组24小时尿蛋白定量,肾功能均有改善,组间比较,P>0.05;治疗组中CCH、TC、FIB、DD及血液流变指标均有明显降低(P<0.05),对照组上述指标降低不明显,组间比较,P>0.05。结论血府逐瘀胶囊能有效缓解早中期糖尿病患者的临床表现,明显改善血瘀症状及生化指标,减少尿蛋白,降低血黏度,以及改善血脂和血液流变学指标。

Clinical Observation of "Xuefu Zhuyu Granule" in Treating Diabetic Nephropathy

To observe the clinical effects of "Xuefu Zhuyu Granule" in the treatment of early and middle diabetic nephropathy,60 subjects were randomized into two groups:treatment group in which 30 cases were treated with this Granule and control group in which another 30 cases were treated with Losartan,with a course of 8 weeks. The clinical symptom score,24-hour urinary protein,kidney function,blood lipid,FIB,DD and blood rheology were observed before and after treatment. Results:The total effective rate was 76.6% in treatment group and 56.7% in control group,P < 0.05;the improvement rate of blood stasis was 84.6% in treatment group and 58.1% in control group,P < 0.05;24-hour urinary protein and kidney function improved little; the CCH,TC,FIB DD and blood rheology improved obviously after treatment in treatment group. It is indicated that this Granule is effective to relieve clinical symptoms and improve laboratory indexes.