新疆维汉民族阻塞性睡眠呼吸暂停低通气综合征患者血清脂肪细胞型脂肪酸结合蛋白水平比较研究

目的探讨新疆维汉民族阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者空腹血清脂肪细胞型脂肪酸结合蛋白(A-FABP)水平变化。方法采取完全随机方法抽取经多道睡眠描记术(PSG)监测确诊为OSAHS的维族及汉族患者各60例,并选取维族及汉族各52例健康体检者作为对照组,测定两组血清A-FABP水平及其他指标。结果 OSAHS患者的血清A-FABP水平与其颈围、腰围、腹围、睡眠呼吸暂停低通气指数(AHI)、体质指数(BMI)、最长呼吸暂停时间均呈正相关(P<0.01),与最低血氧饱和度呈负相关(P<0.01),且其BMI、A-FABP均高于对照组;维族OSAHS患者与汉族OSAHS患者比较,维族患者的BMI、A-FABP高于汉族,差异有统计学意义(P<0.01)。结论 OSAHS患者血清A-FABP水平、BMI高于对照组;维族OSAHS患者BMI、血清A-FABP水平高于汉族OSAHS患者;OSAHS可能是空腹血清A-FABP升高的原因,值得进一步讨论。

Obstructive Sleep Apena Hypopnea Syndrome in Relation to Serum Adipocyte Fatty Acid-Binding Protein:A Comparative Study between Xinjiang Uygur and Han Ethnic Groups

Objective To investigate the relation between obstructive sleep apnea hypopnea syndrome(OSAHS) and fasting serum adipocyte fatty-acid binding protein(A-FABP) in Xinjiang Uygur and Han ethnic groups.Methods A total of 120(60 from each ethnic group) male patients were randomly selected from those diagnosed as having OSAHS by polysomnography(PSG) in our hospital.Another 104 men(52 from each ethnic group) without OSAHS were randomly selected as the control groups from the health checkup subjects.The serum A-FABP level of subjects in the four groups was measured with ELISA.Results The serum A-FABP level of OSAHS patients was positively correlated with the neck circumference,waist circumference,abdominal circumference,apnea hypopnea index(AHI),body mass index(BMI),and the longest apnea time(Tmax)(P<0.01),and was negatively correlated with the lowest oxygen saturation(LSaO2)(P<0.01).The BMI and A-FABP of the OSAHS patients were higher than that of the subjects in the control groups(P<0.05).The serum A-FABP level of the OSAHS patients in Uygur group was significantly higher than that of the Han group(P<0.01).Conclusion OSAHS may cause the increase of fasting serum A-FABP.Further studies are needed to investigate the discrepancy of fasting serum A-FABP levels of Uygur and Han OSAHS patients.