L-精氨酸对家兔动脉粥样硬化斑块形成及血脂的影响

为观察Ｌ－精氨酸对家兔动脉粥样硬化斑块形成及血脂的影响。将４５只新西兰白兔随机分为正常组，对照组和治疗组，正常组用标准饲料喂养，对照组用含２．５％胆固醇的标准饲料及普通饮水喂养，治疗组用含２．５％胆固醇的标准中料及含２．２５％Ｌ－精氨酸的普通饮水喂养，７周及１４周时检测血清总胆固醇及甘油三酯，同时用油经Ｏ将升主动脉及降主动脉染色，利用图像分析仪计算动脉粥样硬化斑块面积百分比。

Effects of L-Arginine on Atherosclerosis and Serum Lipids in Rabbits

Aim To observe the effects of L-arginine on athersclerosis and serum lipids in rabbits. Methods Forty-five rabbits were divided into three groups accidentally. Normal group received nornal chow, control group received 2.5% cholesterol and normal drink, treatment group received 2.5% cholesterol and 2.25% L-arginine solution for 7 or 14 weeks. The levels of serum total cholesterol (TC) and triglycerides (TG) were investigated, while atherosclerosis was measured by image pattern analysis method after ascending aorta and descending aorta were stained with Oil-Red-O. Results The serum total cholesterol and triglycerides had significantly inhibitted by treatment with L-arginine at 7 weeks.But there was no significant difference between treatment with and without L-arginine at 14 weeks. Similar results of atherosclerosis was seen in ascending aorta. But at 7 or 14 weeks, atherosclerosis was less in descending aorta of arginine fed animals than that of rabbits fed cholesterol only. Conclusion The results suggest that chronic dietary L-arginine suppllemintation does not result in a sustained limitation in atherosclerosis and decrease in serum lipids.