程序性细胞死亡因子4在甲状腺乳头状癌组织中的表达及意义

目的  研究程序性细胞死亡因子4（PDCD4）蛋白在甲状腺乳头状癌组织中的表达及临床意义。方法  应用免疫组织化学SP法检测PDCD4蛋白在62例甲状腺乳头状癌、20例癌旁正常组织及28例甲状腺良性肿瘤中的阳性表达，并结合临床资料进行统计学分析。结果  甲状腺乳头状癌组织中PDCD4蛋白的阳性表达率明显低于癌旁正常组织及甲状腺良性肿瘤（P <0.05）。随着PDCD4表达水平的降低，甲状腺乳头状癌恶性程度可能也随之增加（P <0.05）。PDCD4蛋白表达与甲状腺乳头状癌淋巴结转移有统计学意义（P <0.05）。 结论  PDCD4蛋白在甲状腺乳头状癌中低表达，与甲状腺乳头状癌的发生发展有密切联系。

Expression and significance of PDCD4 in thyroid papillary cancer (TPC)

Objective To investigate the expression and significance of PDCD4 in thyroid papillary cancer (TPC). Methods  PDCD4 immunohistochemical expression was investigated in 62 cases of TPC, 20 cases of paracarcinomatous normal tissue and 28 cases of benign thyroid tumor. Their relationship with clinical data was analyzed. Result The positive rate of PDCD4 protein was significantly lower in TPC than that in paracarcinomatous normal tissue and benign thyroid tumor (P < 0.05). And with the decreasing of PDCD4 protein expression level, the malignant degree of TPC increased, which had statistically significant difference among groups (P < 0.05). But the expression of PDCD4 protein had no relationship to lymph node metastasis (P > 0.05). Conclusions The down-regulated expression of PDCD4 protein is correlated with the pathogenesis and development in TPC.