| 白藜芦醇作用于SIRT1影响认知功能的机制研究进展* |
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| 引用本文： | 王德生,苏庆杰,龙发青,张余辉,王布飞,陈斌,夏诗亮. 白藜芦醇作用于SIRT1影响认知功能的机制研究进展*[J]. 中国现代医学杂志, 2020, 30(21): 39-43 |
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| 作者姓名： | 王德生 苏庆杰 龙发青 张余辉 王布飞 陈斌 夏诗亮 |
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| 作者单位： | （海南医学院第二附属医院 神经内科，海南 海口 570311） |
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| 基金项目： | 海南省自然科学基金（No：817337） |
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| 摘 要： | 认知功能减退是与年龄相关的疾病，目前仍无有效的治疗手段。白藜芦醇是一种多酚类化合物，可通过多种途径改善大脑的功能状态，SIRT1的激活是白藜芦醇发挥作用的关键。该文对白藜芦醇的作用机制研究进展，包括抗氧化、抗炎、抗凋亡、改善突触可塑性、增加脑血流量及自噬作用进行综述。
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| 关 键 词： | 白藜芦醇；SIRT1；认知功能 |
| 收稿时间： | 2020-05-02 |
Advances in research on the mechanism of resveratrol improving cognitive function via action on SIRT1* |
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| De-sheng Wang,Qing-jie Su,Fa-qing Long,Yu-hui Zhang,Bu-fei Wang,Bin Chen,Shi-liang Xia. Advances in research on the mechanism of resveratrol improving cognitive function via action on SIRT1*[J]. China Journal of Modern Medicine, 2020, 30(21): 39-43 |
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| Authors: | De-sheng Wang Qing-jie Su Fa-qing Long Yu-hui Zhang Bu-fei Wang Bin Chen Shi-liang Xia |
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| Affiliation: | (Department of Neurology, The Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570311, China) |
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| Abstract: | Cognitive impairment is an age-related disease, for which no effective treatment has been established yet. Resveratrol was a kind of polyphenol that could improve brain function via multiple ways. SIRT1 activation was the key to resveratrol function. This paper is an overview of advances in research on the mechanism of resveratrol, and its antioxidant, anti-inflammatory, anti-apoptotic, synaptic plasticity improving, cerebral blood flow increasing, and autophagy enhancing effects. |
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| Keywords: | resveratrol SIRT1 cognitive function |
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