乳腺癌超声造影特征与病理特征 及免疫组织化学指标的相关性

目的 探讨超声造影对乳腺癌特征评价及其与免疫组织化学指标的相关性。方法 选取2015 年 12 月—2018 年12 月于唐山市妇幼保健院就诊的乳腺癌患者91 例。均为单发病灶，术前行超声造影评价，并 行雌激素受体、孕激素受体及人表皮生长因子受体-2 免疫组织化学指标检测，术后行肿瘤直径、淋巴结转 移及组织学分级病理检测。结果 肿瘤直径>20 mm 患者更易出现高增强、充盈缺损、穿支血管（P <0.05）。 淋巴结转移患者更易出现充盈缺损、穿支血管（P <0.05）。Ⅲ级患者更易出现充盈缺损（P <0.05）。雌激 素受体阴性、人表皮生长因子受体-2 阳性患者更易出现充盈缺损（P <0.05）。增强水平与肿瘤直径呈负相 关（r =-0.343，P <0.05）。充盈缺损与肿瘤直径、组织学分级、雌激素受体呈负相关（r =-0.371、-0.412 和-0.286，均P <0.05）。充盈缺损与淋巴结转移、人表皮生长因子受体-2 呈正相关（r =0.289 和0.527，均 P <0.05）。穿支血管与肿瘤直径、淋巴结转移呈负相关（r =-0.305 和-0.295，均P <0.05）。结论 超声造影 可准确评价乳腺癌特性，与免疫组织化学指标存在密切联系。

Correlation between contrast-enhanced ultrasonography and both pathological features and immunohistochemistry in breast cancer

Objective To investigate correlation between contrast-enhanced ultrasonography and both pathological features and immunohistochemistry in breast cancer. Methods From December 2015 to December 2018, 91 patients with single-lesion breast cancer were selected in Tangshan Maternal and Child Health Hospital. Preoperative contrast-enhanced ultrasound (enhancement level, enhancement mode, filling defect, range change, perforator vessels) were evaluated, while immunohistochemical indexes (estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2) were detected. Pathological examination (tumor diameter, lymph node metastasis, histological grade) were performed after operation. Results Patients with tumor diameter > 20 mm were more likely to have hyperenhancement, filling defect and perforator vessels (P < 0.05). Patients with lymph node metastasis were more likely to have filling defects and perforating vessels (P < 0.05). Grade III patients were more likely to have filling defect (P < 0.05). Patients with negative estrogen receptor and positive human epidermal growth factor receptor-2 were more likely to have filling defect (P < 0.05). Enhancement level was negatively correlated with tumor diameter (r = -0.343, P < 0.05). Filling defect was negatively correlated with tumor diameter, histological grade and estrogen receptor (r = -0.371, -0.412, -0.286, P < 0.05). Filling defect was positively correlated with lymph node metastasis and human epidermal growth factor receptor-2 (r = 0.289, 0.527, P < 0.05). Perforator vessel was negatively correlated with tumor diameter and lymph node metastasis (r = -0.305, -0.295, P < 0.05). Conclusion Contrast-enhanced ultrasound can accurately evaluate characteristics of breast cancer, which is closely related to immunohistochemical parameters.