不同控制水平哮喘患儿血清25(OH)D3、CC16水平和FeNO的变化及临床意义

目的 探讨不同控制水平哮喘患儿血清25-羟维生素D3[25(OH)D3]、Clara细胞分泌蛋白16(CC16)水平和呼出气一氧化氮(FeNO)的临床意义.方法 选取郑州大学附属儿童医院106例哮喘患儿为研究对象,依据哮喘控制水平分级标准分为良好控制组、部分控制组及未控制组.选取同期该院50例健康体检儿童为对照组.采用...

Changes of serum 25(OH)D3, CC16, and FeNO levels in asthmaticchildren with different control levels and their clinicalsignificance*

Objective To explore the serum vitamin D3 [25(OH)D3] levels, Clara cell secretory protein 16 (CC16) levels, and fractional exhaled nitric oxide (FeNO) in asthmatic children with different control levels and its clinical significance. Methods A total of 106 children with asthma were included in the study. According to the classification criteria of asthma control level, it is divided into good control group, partial control group, and uncontrolled group, The control group was 50 healthy children with physical examination during the same period. Serum levels of 25(OH)D3, CC16, IL-4 and VEGF were measured by ELISA, and fractional exhaled nitric oxide (FeNO) was detected. ROC curve was used to evaluate the diagnostic value of 25(OH)D3, CC16, IL-4, VEGF, and FeNO for asthma uncontrolled level. Results The serum levels of 25(OH)D3 and CC16 in asthmatic children were significantly lower than those in the control group, and the uncontrolled group was lower than the control group and the good control group. The serum levels of IL-4 and VEGF in asthmatic children were higher than those in the control group, and uncontrolled group was higher than partial control group and good control group. The level of FeNO in children with asthma was higher than that in the control group, and the uncontrolled group was higher than the part of the control group and the good control group. Serum 25(OH)D3 concentration was positively correlated with CC16 and negatively correlated with IL-4, VEGF, and FeNO levels. The ROC curve analysis showed that the area under the curve of serum 25(OH)D3 and CC16 for the diagnosis of uncontrolled asthma were 0.902 and 0.76. The critical values were 18.523 ng/ml and 10.741 ug/L, the specificities were 83.614% and 76.422% (95% CI: 0.809 and 0.966, P = 0.001), and the sensitivities were 89.214% and 82.725% (95% CI: 0.621 and 0.907, P = 0.003). Conclusion Serum 25(OH)D3 and CC16 in asthmatic children are closely related to asthma control level. Detection of serum 25(OH)D3 and CC16 levels in children with asthma and dynamic monitoring of FeNO are useful for assessing asthma control levels and adjusting treatment options.