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| Omega-3多不饱和脂肪酸对脓毒症相关肠道菌群失调的治疗潜力 | |
| 引用本文： | 汪晨扬,伍静. Omega-3多不饱和脂肪酸对脓毒症相关肠道菌群失调的治疗潜力[J]. 中国现代医学杂志, 2021, 31(4): 71-75 |
| 作者姓名： | 汪晨扬 伍静 |
| 作者单位： | （华中科技大学同济医学院附属协和医院 麻醉科，湖北 武汉 430022） |
| 基金项目： | 国家自然科学基金（No：81772131） |
| 摘 要： | 多样化的肠道菌群正常状态下可以增强宿主防御能力,但在脓毒症状态下,肠道菌群易受到干扰而失调,导致患者预后不佳.如何通过改善肠道菌群失调从而提高脓毒症患者的生存率越来越受到关注.Omega-3多不饱和脂肪酸因具有免疫调节、抗炎等作用,成为诸多脓毒症治疗研究的焦点.该文介绍了脓毒症相关肠道菌群失调的特征,以及Omega-3... |
| 关 键 词： | 脓毒症 胃肠道 Omega-3多不饱和脂肪酸/脂肪酸类,不饱和 |
| 收稿时间： | 2020-08-20 |
Therapeutic potential of omega-3 polyunsaturated fatty acids inalleviating sepsis-related intestinal microbial dysbiosis* |
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| Chen-yang Wang,Jing Wu. Therapeutic potential of omega-3 polyunsaturated fatty acids inalleviating sepsis-related intestinal microbial dysbiosis*[J]. China Journal of Modern Medicine, 2021, 31(4): 71-75 | |
| Authors: | Chen-yang Wang Jing Wu |
| Affiliation: | (Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Scienceand Technology, Wuhan, Hubei 430022, China) |
| Abstract: | Under physiologic conditions, diverse intestinal flora might enhance host responses againstinvading pathogens. However, intestinal flora might be disturbed and collapsed in sepsis which will result in poorprognosis. How to alleviate the intestinal flora dysbiosis and therefore to improve the survival rate of patients withsepsis has drawn growing attention. Omega-3 polyunsaturated fatty acids have become one of the research highlightsdue to their immunomodulatory and anti-inflammatory effects. This article mainly reviews the characteristics ofsepsis-related intestinal microbial dysbiosis and possible roles of omega-3 polyunsaturated fatty acids in amelioratingsepsis-related intestinal microbial dysbiosis, in order to provide a new insight into the treatment of sepsis. |
| Keywords: | sepsis intestinal microbial dysbiosis omega-3 polyunsaturated fatty acids treatment |
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