| 前列腺素E1、黄芪合用对家兔缺血心脏功能的影响 |
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| 引用本文： | 周玉娟,刘福林,张秋燕,王亮,赵学增. 前列腺素E1、黄芪合用对家兔缺血心脏功能的影响[J]. 河北职工医学院学报, 2001, 18(2): 7-8 |
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| 作者姓名： | 周玉娟 刘福林 张秋燕 王亮 赵学增 |
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| 作者单位： | 1. 河北省职工医学院,河北,保定,071000
2. 河北省职工医学院附属医院,河北,保定,071000 |
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| 摘 要： | 目的观察前列腺素E1(8μg·kg-1)与黄芪(225mg·kg-1)合用对家兔缺血心脏功能的影响.方法麻醉家兔冠脉结扎30min后再灌30min,测定左室舒张末期压(LVEDP).结果两药合用的疗效优于单药应用,减少缺血再灌注损伤心律失常的发生(P＜0.01).结论前列腺素E1与黄芪合用对家兔缺血心脏功能的保护有显著的协同作用.
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| 关 键 词： | 合用 缺血 前列腺素E1 心脏功能 黄芪 家兔 单药 目的观 结论 方法 |
| 文章编号： | 1008-6692(2001)02-0007-02 |
| 修稿时间： | 2001-04-17 |
Protective effect of prostaglandin E1 combined with Astragalus membranaceus on ischemic heart model in rabbits |
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| Zhou Yujuan Liu Fulin Zhang Qiuyan et al. Protective effect of prostaglandin E1 combined with Astragalus membranaceus on ischemic heart model in rabbits[J]. Journal of Hebei Medical College for Continuing Education, 2001, 18(2): 7-8 |
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| Authors: | Zhou Yujuan Liu Fulin Zhang Qiuyan et al |
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| Abstract: | Objective To study the effect of prostaglandin E 1(PGE 1) and Astragalus membranaceus,alone or in combination on ischemic heart model in rabbits.Method The experiments were carried out in anesthetized rabbits after coronary artery ligation for 30min followed by reperfusion 30min(with prostaglandin E 1 or Astragalus membranaceus or PGE 1 in combination with Astragalus membranaceus).The left ventricular end diastolic pressure (LVEDP) were determined on 32 hearts.Results PGE 1 in combination with Astragalus membranaceus were more effective than each drug alone at more doses,which obviously increased LV dp/dtmax and reduced the time of continuous arrhythmias(P<0.05).Conclusion PGE 1 in combination with Astragalus membranaceus has protective effects on ischemic heart model in rabbits.There was some synergic effects when they were used in combination. |
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| Keywords: | prostaglandin E_1 astragalus membranaceus ischemic and reperfusion |
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