| BSG基因多态性与中国汉族人群类风湿性关节炎的遗传易感性研究 |
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| 引用本文： | 郭韧,;黄攀豪,;刘作良. BSG基因多态性与中国汉族人群类风湿性关节炎的遗传易感性研究[J]. 中国临床药理学与治疗学, 2014, 0(7): 780-784 |
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| 作者姓名： | 郭韧, 黄攀豪, 刘作良 |
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| 作者单位： | [1]中南大学湘雅三医院药剂科,湖南长沙410013; [2]中南大学湘雅三医院急危重症科,湖南长沙410013 |
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| 基金项目： | 国家自然科学基金项目（81000120） |
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| 摘 要： | 目的：探讨BSG（Basigin）基因多态性与中国汉族人群类风湿性关节炎发病之间的相关性。方法：收集196例类风湿性关节炎患者和249例健康人群，应用PCR-RFLP的分析方法，对BSG基因T-10292A多态性进行基因分型，用ELISA法检测血清中可溶性CD147（sCD147）的表达。结果：病例组与对照组BSG基因T-10292A多态基因型的分布差异存在着统计学意义（P〈0．05）。与正常对照组相比，类风湿性关节炎患者血清中sCD147的浓度显著升高。与其他基因型患者相比，TT基因型患者，其sCD147的浓度最低。结论：BSG基因多态性与中国汉族人群类风湿性关节炎的发病可能相关。
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| 关 键 词： | 类风湿性关节炎 BSG CD147 多态性 |
Association between BSG gene polymorphism and rheumatoid arthritis susceptibility |
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| Affiliation: | GUO Ren, HUANG Pan-hao, LIU Zuo-liang i Department of Pharmacy, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China l z Department of ICU, the Third Xiangya Hospital, Central South Univer- sity, Changsha 410013, Hunan, China |
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| Abstract: | AIM： To investigate the associa- tion of BSG-l0292T/A rs8259 polymorphisms with rheumatoid arthritis susceptibility in a Chi- nese Hart population. METHODS： We per- formed a case-control analysis including a total of 196 cases and 249 healthy controls. Polymer- ase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was used to geno- type the SNP. The expression of sCD147 in ser- um was detected. RESULTS： Our result indica-ted that there is significant difference in the al- lele frequencies between the RA cases and con- trols accompanied with a significant difference in sCD147. CONCLUSION. BSG-10292T/A poly- morphism is associated with rheumatoid arthritis susceptibility in Chinese Han population. |
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| Keywords: | rheumatoid arthritis （RA） BSG CD147 polymorph |
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