Is cholic acid responsible for embryo-toxicity of the post-receptive uterine environment? |
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| Authors: | Psychoyos, A. Roche, D. Gravanis, A. |
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| Affiliation: | 2Department of Pharmacology, School of Medicine, University of Crete Heraklion, Greece Laboratoire de Physiologie de la Reproduction, CNRS UA 549. H?pital de Bic?tre, B?timent INSERM 94270 Le Kremlin-Bic?tre. France |
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| Abstract: | HPLC analysis of the embryo-toxic fraction of human uterinefluid, collected between the 22nd and 25th days of the menstrualcycle, revealed the presence of cholic acid at high concentrations.It is suggested that cholic acid could be responsible for theembryo-toxicity of the uterine environment, which follows thereceptive period for implantation. |
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| Keywords: | cholic acid/human embryo-toxicity/uterine fluid/uterine receptivity |
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