林州市食管癌高发区人群维生素营养状况的动态变化研究

目的了解林州市食管癌高发区人群维生素营养状况的动态变化。方法采用生态学对比研究的方法,在林州市选择曾经进行过营养调查的8个乡,每乡2村,每村随机抽取30户居民为研究对象,采集血样和4h负荷尿,测定血清维生素A,血浆总抗坏血酸,红细胞谷胱甘肽还原酶活性系数分别采用三氟乙酸比色法,2,4二硝基苯肼法和Sauberlich法,尿中核黄素,还原型抗坏血酸,总抗坏血酸排出量分别采用荧光法,2,6二氯酚靛酚滴定法和2,4二硝基苯肼法,测定结果与1982年、1983年和1984年的调查结果进行比较分析,采用t检验或χ2检验。结果任村、东姚和河涧三个乡的居民血清维生素A显著高于1982年的结果(P<0.01);姚村、任村和河顺三个乡的居民4h负荷尿核黄素排出量显著高于1983年或1984年的结果(P<0.01);以4h负荷尿核黄素排出量和红细胞谷胱甘肽还原酶活性系数评价核黄素营养状况发现东姚、河涧、姚村、任村四个乡的居民核黄素缺乏的人数显著低于1982年或1983年的结果(P<0.01);以血浆总抗坏血酸水平及4h负荷尿中抗坏血酸排出量平均值评价维生素C营养状况发现东姚、河涧、姚村、任村和河顺五个乡的居民总抗坏血酸缺乏的人数显著低于1982年或1983年的结果(P<0.01)。结论食管癌高发区林州市居民维生素A,B2,C的营养状况有了明显的改善。

Study on changes of vitamin nutrition status of population in a high-risk area of esophageal cancer

OBJECTIVE: To study the changes of vitamin nutritional status of residents in a high-risk area of esophageal cancer. METHODS: 8 towns where nutrition survey had been done were selected, 2 villages were randomly selected from each town and 30 families were randomly selected per village. The blood and 4h burden urine samples were collected from subjects. The serum vitamin A, blood total ascorbic acid and glutathione reductase activition coefficient (AC) in red blood cell were determinde by using of trifluoroacetic acid colorimetry, 2, 4-dinitrophenylhydrazine colorimetric method and Sauberlich method respectively. The contents of vitamin B2 , reduction ascorbic acid and total ascorbic acid in 4h burden urine were measured by using of fluorescent pectrophotometry,2,6-Dichloro-N-(4-hydroxyphenyl)-1,4-benzoquinoneimine titrimetric method and 2,4-dinitrophenylhydrazine colorimetric method respectively. The results were analyzed and compared with those of in 1980, 1983 and 1984. The t-test or chi2-test was carried out. RESULTS: The level of serum retinal in residents living in Ren cun, Dongyao and Hejian is significantly higher than that of in 1982 (P < 0.01). The level of vitamin B2 in 4h burden urine in residents living in Yaocun, Rencun and Heshun are significantly higher than that of in 1982 or 1984 (P < 0.01). The number of ribflavin deficiency of population living in Dongyao, Hejian, Yaocun and Rencun are significantly lower than that of in 1982 or 1983 (P < 0.01) according to the content of 4h burden urine and glutathione reductase activation coefficient (AC) in red blood cell; the number of vitamin C deficiency of population living in Dongyao, Hejian,Yao cun, Ren cun and Heshun are significantly lower than that of in 1982 or 1983 (P < 0.01) according to blood total ascorbic acid and the ascorbic acid content of 4h-burden urine and. CONCLUSION: Vitamin nutritional status of residents in a high-risk area of esophageal cancer have been improved.