| 右美托咪定抑制慢性吸烟患者气管插管反应的临床研究 |
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| 引用本文： | 徐燕,成建庆,葛叶盈,袁力勇.右美托咪定抑制慢性吸烟患者气管插管反应的临床研究[J].中华全科医师杂志,2014(6):499-501. |
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| 作者姓名： | 徐燕 成建庆 葛叶盈 袁力勇 |
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| 作者单位： | [1]浙江省宁波市李惠利医院麻醉科,315040 [2]宁波市第六医院麻醉科,315040 |
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| 基金项目： | 宁波市优秀中青年卫生技术人才项目（2007201） |
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| 摘 要： | 2012年5月至2013年5月，对60例慢性吸烟男性患者行全身麻醉诱导前静注右美托咪定1μg/kg或等容量生理盐水（各30例）。静注右美托咪定或生理盐水后、麻醉诱导完成后、气管插管后1、3 min时，右美托咪定组患者的心率、心率收缩压乘积明显低于生理盐水组（ P＜0.05）。提示全身麻醉诱导前静注右美托咪定可有效减轻男性慢性吸烟患者气管插管心血管反应，避免心肌氧耗增加，利于保护患者的心脏功能。
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| 关 键 词： | 右美托咪啶 吸烟 |
Inhibitory effects of dexmedetomidine on cardiovascular responses of endotracheal intubation in chronic smokers |
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| Xu Yan,Cheng Jianqing,Ge Yeying,Yuan Liyong.Inhibitory effects of dexmedetomidine on cardiovascular responses of endotracheal intubation in chronic smokers[J].Chinese JOurnal of General Practitioners,2014(6):499-501. |
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| Authors: | Xu Yan Cheng Jianqing Ge Yeying Yuan Liyong |
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| Institution: | ( Department of Anesthesiology, Ningbo Li huili Hospital, Ningbo 315040, Zhejiang, China) |
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| Abstract: | From May 2012 to May 2013, 60 chronic male smokers received an intravenous infusion of dexmedetomidine 1 μg/kg （Group D, n=30） or an equal volume of normal saline （Group C, n=30） before anesthesia induction.At time of dexmedetomidine or normal saline dosing , after induction of anesthesia, 1 and 3 min after intubation, the heart rates and rate-pressure products were significantly lower in Group D than Group C （ P〈0.05 ）.Thus the dosing of dexmedetomidine before anesthesia induction could suppress the cardiovascular responses of endotracheal intubation in chronic smokers and avoid increasing myocardial oxygen consumption so as to protect heart functions. |
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| Keywords: | Dexmedetomidine Smoking |
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