| 通脉灵颗粒的制备及质量控制方法研究 |
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| 引用本文： | 李元平.通脉灵颗粒的制备及质量控制方法研究[J].中国药房,2007,18(6):431-433. |
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| 作者姓名： | 李元平 |
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| 作者单位： | 山西省人民医院药剂科,太原市,030012 |
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| 摘 要： | 目的:制备通脉灵颗粒并建立其质量控制方法。方法:通过回流提取制备通脉灵颗粒;用薄层色谱扫描法对通脉灵颗粒中山楂和葛根进行定性鉴别,并对熊果酸进行含量测定。结果:薄层色谱扫描法对山楂和葛根的定性鉴别专属性强;熊果酸的线性范围为0.990~4.950μg.mL-1(r=0.9998),平均回收率为99.91%(RSD=2.3%)。结论:该制剂制备工艺可行,质量控制方法可靠。
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| 关 键 词： | 通脉灵颗粒 山楂 葛根 熊果酸 |
| 文章编号： | 1001-0408（2007）06-0431-03 |
| 收稿时间： | 2006-07-17 |
| 修稿时间： | 2006-10-18 |
Study on Preparation and Quality Standard of Tongmailing Granules |
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| LI Yuanping.Study on Preparation and Quality Standard of Tongmailing Granules[J].China Pharmacy,2007,18(6):431-433. |
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| Authors: | LI Yuanping |
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| Abstract: | OBJECTIVE: To prepare Tongmailing Granules and establish a quality standard thereof. METHODS: To prepare Tongmailing Granules by reflux extraction, identify the nature of Fructus Crataegi and Radix Puerariae in the granules by TLC, and determine the content of Ursolic Acid through thin layer scanning. RESULTS: TLC identification of Fructus Crataegi and Radix Puerariae is a highly specific approach. Ursolic Acid had a linear calibration curve ranging 0. 990～ 4. 950μ g· mL-1 ( r=0. 999 8) , with recovery rate reaching 99. 91% ( RSD=2. 3% ) . CONCLUSION: This preparation technique is workable, and reliable in quality control. |
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| Keywords: | Tongmailing Granules Fructus Crataegi Radix Puerariae Ursolic Acid |
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