红花黄色素联合阿托伐他汀治疗不稳定型心绞痛的临床研究

目的探讨红花黄色素联合阿托伐他汀治疗不稳定型心绞痛的临床疗效。方法选取2015年3月—2016年2月泸州市人民医院收治的不稳定型心绞痛患者86例,随机分为对照组和治疗组,每组各43例。对照组口服阿托伐他汀钙片,20 mg/次,1次/d。治疗组在对照组基础上静脉滴注注射用红花黄色素,100 mg加入到250 m L生理盐水中,1次/d。两组均连续治疗14 d。观察两组的临床疗效和心电图疗效,比较两组临床症状、炎性指标及血脂指标的情况。结果治疗后,对照组和治疗组的临床疗效的总有效率分别为76.74%、95.35%,两组比较差异有统计学意义(P0.05)。治疗后,对照组和治疗组的心电图疗效的总有效率分别为39.53%、65.11%,两组比较差异有统计学意义(P0.05)。治疗后,两组心绞痛发作频率、持续时间及心绞痛疼痛程度显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的降低程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组hs-CRP、TNF-α及IL-6显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的降低程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组TC、TG及LDL-C显著降低,而HDL-C显著升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论红花黄色素联合阿托伐他汀治疗不稳定型心绞痛具有较好的临床疗效,可改善临床症状,减轻炎症反应,具有一定的临床推广应用价值。

Clinical study on safflower yellow combined with atorvastatin in treatment of unstable angina pectoris

Objective To investigate the clinical effect of safflower yellow combined with atorvastatin in treatment of unstable angina pectoris. Methods Patients (86 cases) with unstable angina pectoris in Luzhou People’s Hospital from March 2015 to February 2016 were randomly divided into the control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the treatment group were iv administered with Safflower Yellow for injection on the basis of the control group, 100 mg added into normal saline 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical and electrocardiographic efficacies were evaluated, and clinical symptoms, inflammatory indexes, and blood lipid indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.74%and 95.35%, respectively, and there was difference between two groups (P<0.05). After treatment, the electrocardiographic efficacies in the control and treatment groups were 39.53% and 65.11%, respectively, and there was difference between two groups (P< 0.05). After treatment, attack frequency, duration, and pain degree of angina pectoris in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, hs-CRP, TNF-α, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, TC, TG, and LDL-C in two groups were significantly decreased, but HDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Safflower yellow combined with atorvastatin has clinical curative effect in treatment of unstable angina pectoris, and improve clinical symptoms, reduce inflammatory reactions, which has a certain clinical application value.