冠心病合并肾动脉狭窄患者检测超敏C-反应蛋白及白介素6的价值

目的探讨超敏C-反应蛋白（Hs-CRP）和白介素6（IL-6）与冠心痛合并肾动脉狭窄（RAS）的价值。方法对经冠状动脉造影确诊为冠心病的246例患者同时进行选择性肾动脉造影，根据肾动脉造影结果分为肾动脉正常组131例，肾动脉病变组59例，RAS组56例。以放射免疫法检测血清IL-6，免疫比浊法检测Hs-CRP。结果RAS组血清IL-6和Hs-CRP水平明显高于肾动脉正常组和肾动脉病变组（P〈0．01）；肾动脉病变组的IL-6和Hs—CRP水平明显高于肾动脉正常组（P〈0．01）；RAS患者Hs-CRP与IL-6显著正相关（P〈0．01）。结论冠心病并RAS存在炎症反应，IL-6和Hs—CRP是冠心病并RAS的重要危险因素及预测因子。

The analysis about the levels of high sensitive C-reactive protein and the interleukin-6 in the coronary heart disease patients with renal artery stenosis

Objective To investigate the relationship between the level of high sensitive C-reactive protein(Hs-CRP)and interleukin-6(IL-6) and renal artery stenosis in coronary heart disease.Methods Renal arteriographies were performed at the same time in 246 patients who underwent coronary angiographies in our hospital from March 2004 to December 2005.All the patients were divided into three groups according to the results of renal arteriography,131 patients with normal renal artery,59 patients with pathological renal artery,56 patients with renal artery stenosis(RAS).The serum levels of IL-6 and Hs-CRP were measured with enzyme-linked immunosorbent assay(ELISA) and immunonephelometry respectively.Results The serum levels of IL-6 and Hs-CRP were significantly higherin the RAS group than the normal renal artery and the pathological renal artery group(P<0.01).The serum levels of IL-6 and Hs-CRP were significantly higher in the pathological renal artery group than the normal renal artery(P<0.01).Conclusion Inflammation response lies in coronary heart disease and renal artery stenosis.IL-6 and Hs-CRP are important dangerous factors and estimating factors.