慢性阻塞性肺疾病急性加重期患者抵抗素与肺功能相关性研究

目的 通过测定慢性阻塞性肺疾病急性加重期(AECOPD)患者血浆抵抗素水平,探讨其与肺功能的相关性.方法 采用酶联免疫吸附法(ELISA)测定46例AECOPD患者和40例正常对照者(NC)血清抵抗素及肺功能,分析相关因素.结果 AECOPD组患者的血清抵抗素及肺通气功能指标与对照组比较差异均有统计学意义(P＜0.05).单因素直线相关分析显示,AECOPD患者血清抵抗素水平与FEV1.0、FEV1.0％预计值、FEV1/FVC显著相关(r值分别为0.359、0.308、0.457、0.689),与BMI无显著相关性.多元逐步回归分析表明,影响患者血清抵抗素的主要因素是FEV1.0、FEV1.0％预计值.结论 对于AECOPD患者,抵抗素参与机体炎症反应,其水平升高是肺组织慢性损伤、功能降低的重要原因.

Correlation between resistin and lung function in acute exacerbation of COPD with hyperglycemia

Objective To determine serum resistin level in patients with chronic obstructive pulmonary disease with acute exacerbation(AECOPD) and explore its correlation with lung function.Methods The enzyme-linked immunosorbent assay(ELISA) was used for determining serum resistin,TNF-a of 46 patients with AECOPD and 40 normal controls(NC) and tested lung function,and analyzed relevant factors.Results Compared with control group,the serum resistin,TNF-a and lung function were statistically different AECOPD patients.Univariate linear correlation analysis showed that serum resistin levels in patients with COPD and FEV1,FEV1% predicted,FEV / FVC,TNF-α was significantly correlated(r=0.359,r=0.308,r=0.457 and r=0.689),and BMI no significant correlation.Multiple stepwise regression analysis showed that serum resistin affected the main factor is the FEV,FEV1% predicted and TNF-α.Conclusion For patients with AECOPD,resistance factors involve in inflammatory response,the levels of chronic lung tissue damage,reduction in functionality is the main reason.