西酞普兰与阿普唑仑治疗广泛性焦虑障碍对照研究

目的 探讨西酞普兰(喜太乐)治疗广泛性焦虑障碍的临床疗效.方法 将64例广泛性焦虑障碍患者分成2组,每组32例.研究组口服西酞普兰治疗,对照组口服阿普唑仑治疗,观察4周,于治疗前及治疗2、4周末采用救密顿焦虑量表(HAMA)评定临床疗效,于治疗4周后用TESS评定不良反应.结果 治疗结束时2组HAMA评分均较治疗前显著下降(P＜0.01),2组间比较差异无统计学意义(P＞0.05).治疗4周后研究组总有效率为75.00％,对照组总有效率为78.12％,2组比较无统计学意义(P＞0.05)；治疗4周后研究组较对照组不良反应少于对照组(P＜0.05).结论 西酞普兰治疗广泛性焦虑障碍疗效显著,与阿普唑仑相当,且不良反应较阿普唑仑少,可作为治疗广泛性焦虑障碍的一线用药.

A control study of Citalopram and Alprazolam in treatment of generalized anxiety disorder

Objective To explore the clinical efficacy of Citalopram in the treatment of generalized anxiety disorder(GAD).Methods 64 patients with generalized anxiety disorder were divided into two groups,the patients in research group(n=32) took orally Citalopram and control group(n=32) did Alprazolam for 4 weeks.Clinical efficacy was assessed with the Hamiton Anxiety Scale(HAMA) before and at the end of the 2nd and 4th week treatment.Results After treatment the HAMA scores of both groups significantly decreased compared with pretreatment(P<0.01),the total effective rates were respectively 75% in research group and 78.1% in the control group at the end of the 4th week,which showed no significant difference.Conclusion Citalopram has significant curative effect equivalent to alprazolam on GAD and can be used as first-line drug for GAD.