急性颅脑损伤患者细胞因子与NSE水平变化的临床意义

目的探讨急性颅脑损伤患者肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）及神经元特异性烯醇化酶（NSE）水平的变化。方法测定80例急性颅脑损伤患者和30例正常对照者的血清TNF-α、IL-6及NSE水平．并分析各参数之间的相关性。结果颅脑损伤患者TNF-α（3．9±1．1ng／L）、IL-6（189．8±42．6ng/L）及NSE（28．7±8．5ng／L）水平显著高于对照组（0．7±0．3ng／L，68．5±22．7ng／L，8．1±4．2．g／L），P〈0．01，轻、中、重型颅脑损伤患者TNF-α、IL-6及NSE水平差异有统计学意义（P〈0．05）；NSE与TNF-α及IL-6水平正相关，相关系数分别为0．85（P〈0．01）和0．88（P〈0．01）。结论TNF-α、IL-6及NSE在急性颅脑损伤中具有重要作用，并与病情严重程度密切相关，病程早期检测TNF-α、IL-6及NSE水平有助于中、重型颅脑损伤的预测．

Dynamic changes and clinical significance of serum cytokines and neuron specific enolase of patients with acute brain injury

Objective To explore the relationship of serum eytokines and neuron specific enolase level in patients of acute brain injury. Methods Serum interleukin-6（IL-6）,tumor necrosis factor-alpha（TNF-α）and neuron specific enolase（NSE）were measured in acute brain injury （80 cases）and control group （30 cases）. The relations between these indices were assayed. Results Serum levels of TNF-α, IL-6 and NSE had significant difference with controls group. TNF-α,IL-6 and NSE levels in serum in patients with severe brain injury were significantly higher than in those with mild brain injury（P〈0.05 ）. NSE was posi- tive correlated with TNF-α, IL-6, r=0.85,0.80 respectively, which were very significantly different （P〈0.01）. Conclusions TNF-α,IL-6 and NSE levels in plasma had significantly correlated with degree of injury severity. The measurement of TNF-α,IL-6 and NSE levels in serum may contribute to predict the severity of brain injury.