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| 小鼠自然老化过程中耳蜗的糖代谢障碍 | |
| 引用本文： | 丁大连,李明,王坚. 小鼠自然老化过程中耳蜗的糖代谢障碍[J]. 临床耳鼻咽喉头颈外科杂志, 1998, 12(1): 6-8 |
| 作者姓名： | 丁大连 李明 王坚 |
| 作者单位： | 纽约BUFFALO大学听力与耳聋中心(丁大连，王坚，胡博华，郑向阳，SalviRJ)，佳木斯医学院附属医院耳鼻咽喉科(李明) |
| 摘 要： | 应用定量组织化学技术分析了ＣＢＡ和Ｃ５７ＢＬ小鼠耳蜗中糖元代谢的改变，发现１８个月和３６个月龄ＣＢＡ小鼠的毛细胞和血管纹中，糖元含量比６周龄ＣＢＡ正常小鼠明显增高，说明在自然老化ＣＢＡ小鼠耳蜗中存在糖元储积现象。 |
| 关 键 词： | 鼠 耳蜗 糖代谢障碍 老化 |
Glycogenosis in cochlea of aging mice |
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| Ding Dalian. Glycogenosis in cochlea of aging mice[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 1998, 12(1): 6-8 | |
| Authors: | Ding Dalian |
| Affiliation: | Center for Hearing and Deafness, University at Buffalo, State University of New York, USA. |
| Abstract: | CBA/Caj mice and C57BL/6Nsd mice (animal models widely used for study of presbycusis) were used to study glycogen metabolic changes in the aging cochlea by a quantitative analysis of histochemistry. Glycogen contents in both hair cells and stria vacularis were significantly increased in CBA aged mice (18 and 36 months) as compared with those in CBA young animals (6 weeks), indicating a glycogenosis in the cochlea within naturally aging CBA mice. The glycogen contents in the stria vascularis in C57BL mice (6 weeks) was higher than in CBA (6weeks) mice, whereas no significant difference could be discerned in the hair cell glycogen level.The results suggest that the glycogen metabolic changes in the CBA mice, a model of the natural aging cochlea, were different from in the C57 mice, a model of the cochlear genetic defect. |
| Keywords: | Glycogen Inner ear Mice |
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