| 纳米羟基磷灰石复合胶原/聚乳酸材料复合兔骨髓基质细胞异位成骨的实验研究 |
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| 引用本文： | 刘冰,陈鹏,毛天球,岳进. 纳米羟基磷灰石复合胶原/聚乳酸材料复合兔骨髓基质细胞异位成骨的实验研究[J]. 口腔医学研究, 2007, 23(3): 264-266 |
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| 作者姓名： | 刘冰 陈鹏 毛天球 岳进 |
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| 作者单位： | 空军总医院口腔科,北京,100036;解放军总医院口腔科;第四军医大学口腔医院口腔颌面外科 |
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| 摘 要： | 目的：观察nHAC/PLA复合兔BMSCs的异位成骨能力.方法：通过负压吸附使BMSCs与nHAC/PLA材料复合,将nHAC/PLA＋自体BMSCs、自体BMSCs、nHAC/PLA材料分别植入新西兰兔背部肌袋内,术后4、8周通过大体、组织学观察来研究其异位成骨能力.结果：自体BMSCs组与nHAC/PLA材料组在新西兰兔背部肌袋内均无骨质形成,nHAC/PLA＋自体BMSCs组8周时有大量较成熟的骨质形成,同时材料本身部分吸收.结论：通过负压吸附的方法制备出的nHAC/PLA＋自体BMSCs具有良好的异位成骨能力.
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| 关 键 词： | 纳米羟基磷灰石复合胶原/聚乳酸材料 骨髓基质细胞 异位成骨 组织工程 |
| 文章编号： | 1671-7651（2007）03-0264-03 |
| 修稿时间： | 2006-10-13 |
Ectopic bone Formation of Nano-hydroxyapatite/collagen/PLA Material Compound with Rabbit BMSCs. |
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| LIU Bing, CHEN Peng, MAO Tianqiu. Ectopic bone Formation of Nano-hydroxyapatite/collagen/PLA Material Compound with Rabbit BMSCs.[J]. Journal of Oral Science Research, 2007, 23(3): 264-266 |
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| Authors: | LIU Bing CHEN Peng MAO Tianqiu |
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| Affiliation: | Department of Stomatology, General Air Force Hospital of PLA, Beijing 100036 |
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| Abstract: | Objective:To observe the ability of ectopic bone formation of nHAC/PLA compound with rabbit BMSCs.Methods:The combination of BMSCs and nHAC/PLA in vitro was made through negative pressure adsorbing.nHAC/PLA+autoallergic BMSCs and autoallergic BMSCs,nHAC/PLA material were implanted into musclar pouch of New-Zealand rabbit back,respectively.After four weeks and eight weeks,the ability of ectopic bone formation was tested through gross histology observation.Results:Neither autoallergic BMSCs nor nHAC/PLA material was sclerotized in the musclar pouch of New-Zealand rabbit back.The nHAC/PLA+ autoallergic BMSCs was maturely sclerotized in large amount after 8 weeks.The material was partly absorbed.Conclusion:The nHAC/PLA+ autoallergic BMSCs produced by negative pressure adsorbing has a good ability of ectopic bone formation. |
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| Keywords: | Nano-hydroxyapatite/collagen/PLA material(nHAC/PLA) Bone marrow stromal cells(BMSCs) Ectopic bone formation Tissue engineering |
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