洛铂联合热疗治疗恶性胸腔积液疗效观察

目的：观察洛铂联合局部热疗胸腔灌注治疗恶性胸腔积液的疗效和不良反应。方法：将46例恶性胸腔积液的患者，随机分为两组，排尽胸水后，给予胸腔化疗，用药洛铂、IL-2，治疗组进行患侧胸腔热疗；对照组无热疗。结果：A组控制胸水的总有效率为84．6％，B组为61．3％（P〈0．05），A组与B组生活质量好转率分别为80．5％和47．1％（P〈0．05）。结论：热疗联合胸腔灌注化疗治疗恶性胸腔积液有协同作用。

Clinical observation on treating malignant plenral effusion by Luobo plus hyperthermia

Objective： To observe the effect and adverse reaction of therapy on malignant plural effusion by thermotherapy combined with lobaplatin for injection. Methods： To divide 46 patient s of malignant plural effusion into two groups （A and B） randomly, after exhaustion of hydrothorax, administration of thoracic cavity chemotherapy, medication of LBP, IL-2, therapy group （A） was carded by thoracic cavity chemotherapy, the control group with no hyperthermia. Results： The total effective rate of A group was 84.6%, while group B was 61.3% （P〈0.05）, the quality of life improvement rate A and B group were 80.5% and 47.1% （P〈0.05） respectively. Conclusion： Therapy on malignant plural effusion by lobaplatin for injection combined with thoracic cavity chemotherapy induces synergism effect.