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| HPLC法测定盐酸溴己新注射液含量及有关物质 | |
| 引用本文： | 孙莉. HPLC法测定盐酸溴己新注射液含量及有关物质[J]. 安徽医药, 2008, 12(2): 121-122 |
| 作者姓名： | 孙莉 |
| 作者单位： | 安徽省芜湖市药品检验所,安徽,芜湖241001 |
| 摘 要： | 目的建立HPLC法测定盐酸溴己新注射液含量及有关物质。方法用Phenomenex C18柱（150mm×4．6mm，5μm），以1％醋酸水溶液-甲醇（40：60）为流动相，流速为1.0 ml·min^-1，检测波长为250nm。结果盐酸溴己新线性范围为20.13-201.30mg·L^-1（r=0.9998）；平均回收率为100.4％，RSD为0.48％。结论该方法灵敏，快速，结果准确，可用于盐酸溴己新注射液的质量控制。 |
| 关 键 词： | HPLC 盐酸溴己新注射液 含量 有关物质 |
| 收稿时间： | 2007-11-20 |
| 修稿时间： | 2007-11-20 |
Determination of bromhexine hydrochloride injection and its related substances by HPLC |
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| SUN Li. Determination of bromhexine hydrochloride injection and its related substances by HPLC[J]. Anhui Medical and Pharmaceutical Journal, 2008, 12(2): 121-122 | |
| Authors: | SUN Li |
| Affiliation: | SUN Li ( Wuhu Institute for Drug Control,Wuhu,Anhui Province 241001 ) |
| Abstract: | Aim To establish a method for determination of bromhexine hydrochloride injection and its related substances. Method The column was Phenomenex C18 column（ 150 mm×4.6 mm, 5μm）. The mobile phase was 1% acetic acid-methanol（40：60）, The flow-rate was 1.0 ml·min^-1, and the detection wave length was 205 nm, Results The calibration curves of bromhexine hydrochloride ranged from 20.13 to 201.30 mg·L^-1（ r=0.9998）, The average recovery rate was 100.4% and RSD was 0.48%, Conclusion The method is sensitive, accurate and rapid, It can be used to determine the content of bromhexine hydrochloride injection and its related substances. |
| Keywords: | HPLC bromhexine hydrochloride injection content related substances |
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