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| 冠心平对麻醉犬冠脉结扎致心肌缺血的保护作用 | |
| 引用本文： | 李莲静,李七一,朱萱萱,严士海,朱长乐,王海丹,朱吾元,万盟.冠心平对麻醉犬冠脉结扎致心肌缺血的保护作用[J].现代中西医结合杂志,2011,20(34):4337-4338,4460. |
| 作者姓名： | 李莲静 李七一 朱萱萱 严士海 朱长乐 王海丹 朱吾元 万盟 |
| 作者单位： | 1. 南京中医药大学附属医院江苏省中医院,江苏,南京,210029;南京中医药大学,江苏,南京,210029 2. 南京中医药大学附属医院江苏省中医院,江苏,南京,210029 3. 南京中医药大学,江苏,南京,210029 |
| 基金项目： | 江苏省康缘中医药科技创新与奖励基金 |
| 摘 要： | 目的研究冠心平对麻醉犬冠脉结扎致心肌缺血的保护作用。方法采用麻醉开胸犬冠状动脉左前降支结扎造成急性心肌缺血模型,将36只Beagle犬随机分为假手术组,模型组,心可舒组及冠心平大、中、小剂量组,每组6只。观察给药后犬血清肌酸激酶(CK)、乳酸脱氢酶(LDH)水平的变化。通过N-BT染色,观察心肌梗死的范围。结果冠心平组犬血清中LDH和CK的浓度较其余组显著降低,心肌梗死范围较其他组显著缩小。结论冠心平能明显减轻犬心肌梗死时的心肌缺血程度,从而保护心肌。 |
| 关 键 词： | 冠心平 心肌缺血 麻醉犬 冠脉结扎 |
Protection of Guanxinping for myocytes in anesthetic dog with myocardial ischemia caused by coronary artery ligation |
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| Li Lianjing,Li Qiyi,Zhu Xuanxuan,Yan Shihai,Zhu Changle,Wang Haidan,Zhu Wuyuan,Wan Meng.Protection of Guanxinping for myocytes in anesthetic dog with myocardial ischemia caused by coronary artery ligation[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2011,20(34):4337-4338,4460. | |
| Authors: | Li Lianjing Li Qiyi Zhu Xuanxuan Yan Shihai Zhu Changle Wang Haidan Zhu Wuyuan Wan Meng |
| Institution: | Li Lianjing1,2,Li Qiyi1,Zhu Xuanxuan1,Yan Shihai1,Zhu Changle1,Wang Haidan2,Zhu Wuyuan2,Wan Meng2(1.The Traditional Chinese Medical Hospital of Jiangsu Province,Nanjing 210029,Jiangsu,China,2.Nanjing University of Traditional Chinese Medicine,China) |
| Abstract: | Objective It is to study the protection of Guanxinping for myocytes in anesthetic dog with myocardial ischemia caused by coronary artery ligation.Methods The acute myocardial ischemic canine models were established by left anterior descending artery ligature after opening thoracic cavity under anesthesia.Totally 36 Beagle dogs were randomly assigned to six groups,which were the sham operation group,model group,Xinkeshu group,and Guanxinpin groups with large,median,and small doses of the drugs.The concentrat... |
| Keywords: | Guan xinping myocardial ischemia anesthetic dog coronary artery ligation |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |