甲氨蝶呤不同用药方式治疗异位妊娠的疗效及致肝功能损害的临床分析

目的 探讨甲氨蝶呤（MTX）不同用药方式治疗非破裂型异位妊娠的疗效及致肝功异常的临床特点.方法 将203例非破裂型异位妊娠患者随机分为三组：A组98例患者给予MTX 50～75 mg单次肌注＋米非司酮共300 mg,50 mg/次,口服,1次/12h.B组52例患者给予MTX 50～75 mg单次肌注.C组53例患者给予MTX 50～75 mg两次肌注.结果 三组疗效比较,A组及C组的疗效均明显优于B组疗效,差异有统计学意义（P〈005）;A组及C组的疗效比较,差异无统计学意义,但C组患者药物治疗致肝功能损害明显高于A组,差异有统计学意义（P〈005）.结论 三种用药方式治疗非破裂型异位妊娠均相对安全,甲氨蝶呤联合米非司酮疗效更明显,且致肝功能损害的副作用小.

The clinical analysis of ectopic pregnancy treated with methotrexate by different ways including cause liver damage

Objective To investigate clinical efficacy and liver damage of methotrexate combined with mifepristone for non - ruptured ectopie pregnancy in different way. Methods 203 cases with ectopic pregnancy were randomly divided into three groups：A group ,98 cases were treated with methotrexate 50 -75 mg a single intramuscular injection plus mifepristone total of 300 mg, 50 mg per injection by oral, every 12 hours. B group, 52 cases were treated with methotrexate 50 -75 mga single intramuscular injection. C group, 53 cases were treated with methotrexate 50 - 75 mg two intramuscular injections. Re- suits During comparison among three groups, A and C group were significantly better than the curative effect of group B cura- tive effect, which have significant difference （P 〈 0. 05）. The same effect exist between Group A and C, but liver damage of the group Cis obviously higher than the group A, which is significant difference （ P 〈 0.05 ）. Conclusion Three ways of drug treatment the rupture type ectopic pregnancies are relatively safe, but methotrexate, coupling mifepristone, have more safe and effective.